A F508del-CFTR corrector
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KM 11060

Item No. 23481

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-chloro-4-[4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl]-quinoline
CAS Number
774549-97-2
Molecular Formula
C19H17Cl2N3O2S
Formula Weight
422.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 2 mg/mlEthanol: 0.5 mg/ml
λmax
201, 227, 321 nm
SMILES
ClC1=CC=C(S(N2CCN(C3=CC=NC4=C3C=CC(Cl)=C4)CC2)(=O)=O)C=C1
InChi Code
InChI=1S/C19H17Cl2N3O2S/c20-14-1-4-16(5-2-14)27(25,26)24-11-9-23(10-12-24)19-7-8-22-18-13-15(21)3-6-17(18)19/h1-8,13H,9-12H2
InChi Key
GIEHIZKCIZLXLF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $99

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    10 mg

    $178

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    25 mg

    $391

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    50 mg

    $489

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    Product Description

    KM 11060 is a small molecule that corrects the processing of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing the F508 deletion (F508del) mutation carried by 90% of cystic fibrosis patients.1 It increases cell surface expression and restores chloride transport function of F508del-CFTRs in BHK cells at a concentration of 10 μM. KM 11060 restores F508del-CFTR function, as measured by cAMP-stimulated iodide efflux, in CFBE41o- human airway epithelial cells at a concentration of 10 nM. It also restores the secretory response to approximately 51% of wild-type levels ex vivo in ileum isolated from F508del-CFTR mice at a concentration of 20 μM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Robert, R., Carlile, G.W., Pavel, C., et al. Structural analog of sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect. Mol. Pharmacol. 73(2), 478-489 (2008).