An antioxidant
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Nicaraven

Item No. 23482

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N'-(1-methyl-1,2-ethanediyl)bis-3-pyridinecarboxamide
CAS Number
79455-30-4
Molecular Formula
C15H16N4O2
Formula Weight
284.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 10 mg/mlEthanol: 2 mg/mlPBS (pH 7.2): 2 mg/ml
λmax
212, 263 nm
SMILES
O=C(NCC(C)NC(C1=CN=CC=C1)=O)C2=CN=CC=C2
InChi Code
InChI=1S/C15H16N4O2/c1-11(19-15(21)13-5-3-7-17-10-13)8-18-14(20)12-4-2-6-16-9-12/h2-7,9-11H,8H2,1H3,(H,18,20)(H,19,21)
InChi Key
KTXBOOWDLPUROC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $63

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    25 mg

    $128

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    Cayman Chemical
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    Product Description

    Nicaraven is an antioxidant that exhibits hydroxyl radical scavenging activity in vitro.1 Nicaraven (1-3 mg/kg per min, i.v.) reduces occurrence of chronic cerebral vasospasms in a dose-dependent manner in a canine model of subarachnoid hemorrhage. In a canine model of warm hepatic ischemia and reperfusion injury, nicaraven (2 mg/kg per min, i.v.) reduces liver enzyme release and inhibits lipid peroxidation and neutrophil infiltration in the liver.2 Nicaraven (100 mg/kg per day, i.p.) also decreases plasma levels of the inflammatory cytokines Il-6 and Tnf-α and the urinary levels of 8-oxo-2'-deoxyguanosine, a marker of DNA oxidation, in a mouse model of radiation-induced injury.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Asano, T., Sasaki, T., Koide, T., et al. Experimental evaluation of the beneficial effect of an antioxidant on cerebral vasospasm. Neurol. Res. 6(1-2), 49-53 (1984).

    2. Yokota, R., Fukai, M., Shimamura, T., et al. A novel hydroxyl radical scavenger, nicaraven, protects the liver from warm ischemia and reperfusion injury. Surgery 127(6), 661-669 (2000).

    3. Kawakatsu, M., Urata, Y., Imai, R., et al. Nicaraven attenuates radiation-induced injury in hematopoietic stem/progenitor cells in mice. PLoS Biol. 8(3), e60023 (2013).