An inhibitor of voltage-gated sodium channels
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Raxatrigine (hydrochloride)

Item No. 23490

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S)-5R-[4-[(2-fluorophenyl)methoxy]phenyl]-2-pyrrolidinecarboxamide, monohydrochloride
CAS Number
934240-31-0
Synonyms
  • BIIB074
  • CNV1014802
  • GSK1014802A
  • Vixotrigine
Molecular Formula
C18H19FN2O2 • HCl
Formula Weight
350.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMSO: 33 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
229 nm
SMILES
FC1=CC=CC=C1COC2=CC=C([C@@H]3N[C@H](C(N)=O)CC3)C=C2.Cl
InChi Code
InChI=1S/C18H19FN2O2.ClH/c19-15-4-2-1-3-13(15)11-23-14-7-5-12(6-8-14)16-9-10-17(21-16)18(20)22;/h1-8,16-17,21H,9-11H2,(H2,20,22);1H/t16-,17+;/m1./s1
InChi Key
HEPUBAGOKRIZEO-PPPUBMIESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    Raxatrigine is an inhibitor of voltage-gated sodium channels (Nav; IC50s = 22, 13, 23, 10, 84, 15, 32, and 6 µM for Nav1.1-Nav1.8 channels in a FLIPR membrane potential assay using HEK293 cells).1 Its activity is state-dependent at the Nav1.7 channel, with a nine-fold increase in potency for the open/inactivated state (IC50 = 6.3 µM) compared to the closed/resting state (IC50 = 54 µM). Raxatrigine (30 mg/kg, i.p.) decreases spontaneous pain behavior in an OD1 mouse pain model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Deuis, J.R., Wingerd, J.S., Winter, Z., et al. Analgesic effects of GpTx-1, PF-04856264 and CNV1014802 in a mouse model of NaV1.7-mediated pain. Toxins (Basel) 8(3), 78 (2016).