An intermediate in the ethylmalonyl CoA pathway in bacteria
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Product Categories

Product Type

Biochemicals

Research Area

Endocrinology & Metabolism
Cofactors & Vitamins

Ethylmalonyl Coenzyme A (sodium salt)

Item No. 23503

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
S-(hydrogen 2-ethylpropanedioate) coenzyme A, sodium salt
Synonyms
  • Ethylmalonyl-CoA
Molecular Formula
C26H42N7O19P3S • XNa
Formula Weight
881.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
257 nm
SMILES
O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(C(C(O)=O)CC)=O)=O)=O)(O)=O)(O)=O)[C@H]1OP(O)(O)=O.[Na]
InChi Code
InChI=1S/C26H42N7O19P3S.Na/c1-4-13(24(38)39)25(40)56-8-7-28-15(34)5-6-29-22(37)19(36)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-18(51-53(41,42)43)17(35)23(50-14)33-12-32-16-20(27)30-11-31-21(16)33;/h11-14,17-19,23,35-36H,4-10H2,1-3H3,(H,28,34)(H,29,37)(H,38,39)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43);/t13?,14-,17-,18-,19+,23-;/m1./s1
InChi Key
YQTCSEODFMFYOX-NDLPDMIRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $95

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    1 mg

    $178

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    5 mg

    $601

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    10 mg

    $1,014

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    Product Description

    Ethylmalonyl coenzyme A (CoA) is a key intermediate in the ethylmalonyl-CoA pathway for carbon metabolism in certain bacteria, such as M. extorquens, which uses this pathway when grown on ethylamine.1,2 It is produced from crotonyl-CoA by crotonyl-CoA reductase/carboxylase and modified by ethylmalonyl-CoA mutase to make methylsuccinyl-CoA.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Good, N.M., Martinez-Gomez, N.C., Beck, D.A.C., et al. Ethylmalonyl coenzyme A mutase operates as a metabolic control point in Methylobacterium extorquens AM1. J. Bacteriol. 197(4), 727-735 (2015).

    2. Anthony, C. How half a century of research was required to understand bacterial growth on C1 and C2 compounds; the story of the serine cycle and the ethylmalonyl-CoA pathway. Sci. Prog. 94(Pt 2), 109-137 (2011).