A flavanonol with diverse biological activities
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Dihydromyricetin

Item No. 23549

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R,3R)-2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one
CAS Number
27200-12-0
Synonyms
  • (+)-Dihydromyricetin
Molecular Formula
C15H12O8
Formula Weight
320.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:10): 0.5 mg/mlEthanol: 1 mg/ml
λmax
208, 291 nm
SMILES
OC1=CC(O)=C(C([C@H](O)[C@@H](C2=CC(O)=C(O)C(O)=C2)O3)=O)C3=C1
InChi Code
InChI=1S/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1
InChi Key
KJXSIXMJHKAJOD-LSDHHAIUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    50 mg

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    Product Description

    Dihydromyricetin is a natural flavanonol isolated from A. grossedentata, H. dulcis, and other plants that has antioxidant, antiproliferative, anti-apoptotic, and anti-alcohol intoxication properties.1,2,3,4,5,6 Dihydromyricetin scavenges 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals (IC50 = 0.235 μg/ml) and decreases reactive oxygen species (ROS) generated by AAPH (Item No. 82235) in human erythrocytes when used at a concentration of 6 μg/ml.3 It dose-dependently decreases proliferation and increases apoptosis in human liver carcinoma HepG2 cells, but does not affect proliferation of normal hepatic HL7702 cells.4 In vivo, it decreases tumor volume by 43.5% in a HepG2 mouse xenograft model when administered at a dose of 500 mg/kg per day.5 Dihydromyricetin binds to GABAA receptors in rat cortical membrane reparations (IC50 = 4.36 μM) and dose-dependently reduces loss of righting reflex (LORR) in ethanol-intoxicated rats.6 It also improves cognitive deficits in a mouse model of Alzheimer's disease when administered at 2 mg/kg for three months.7

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Muhammad, U., Lu, H., Wang, J., et al. Optimizing the maximum recovery of dihydromyricetin from Chinese Vine Tea, Ampelopsis grossedentata, using response surface methodology. Molecules 22(12), E2250 (2017).

    2. Hyun, T.K., Eom, S.H., Yu, C.Y., et al. Hovenia dulcis--an Asian traditional herb. Planta. Med. 76(10), 943-949 (2010).

    3. Liao, W., Ning, Z., Ma, L., et al. Recrystallization of dihydromyricetin from Ampelopsis grossedentata and its anti-oxidant activity evaluation. Rejuvenation Res. 17(5), 422-429 (2014).

    4. Liu, B., Tan, X., Liang, J., et al. A reduction in reactive oxygen species contributes to dihydromyricetin-induced apoptosis in human hepatocellular carcinoma cells. Sci. Rep. 4, 7041 (2014).

    5. Zhang, Q., Liu, J., Liu, B., et al. Dihydromyricetin promotes hepatocellular carcinoma regression via a p53 activation-dependent mechanism. Sci. Rep. 4, 4628 (2014).

    6. Shen, Y., Lindemeyer, A.K., Gonzalez, C., et al. Dihydromyricetin as a novel anti-alcohol intoxication medication. J. Neurosci. 32(1), 390-401 (2012).

    7. Liang, J., Lopez-Valdes, H.E., Martinez-Coria, H., et al. Dihydromyricetin ameliorates behavioral deficits and reverses neuropathology of transgenic mouse models of Alzheimer’s disease. Neurochem. Res. 39(6), 1171-1181 (2014).