An inhibitor of SOD1
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ATN-224

Item No. 23553

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-hydroxy-N,N,N-trimethyl-ethanaminium, tetrathioxomolybdate
CAS Number
649749-10-0
Synonyms
  • Bis-Choline Tetrathiomolybdate
Molecular Formula
C5H14NO • 1/2MoS4
Formula Weight
432.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
242, 315, 468 nm
SMILES
C[N+](C)(C)CCO.C[N+](C)(C)CCO.S=[Mo-2](=S)(=S)=S
InChi Code
InChI=1S/2C5H14NO.Mo.4S/c2*1-6(2,3)4-5-7;;;;;/h2*7H,4-5H2,1-3H3;;;;;/q2*+1;-2;;;;
InChi Key
XTDZSQBNDXNMJY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $83

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    10 mg

    $152

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    25 mg

    $275

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    Cayman Chemical
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    Product Description

    ATN-224 is a choline salt of tetrathiomolybdate and an inhibitor of superoxide dismutase 1 (SOD1; IC50s = 2.91 and 3.51 µM in human and mouse blood cells, respectively, in vitro).1 ATN-224 reduces the viability of cultured oxidative stress-resistant WEHI7.2 murine thymic lymphoma cells (EC50s = 5-6 nM) and human diffuse large B cell lymphoma cell lines (EC50s = 9.73-105.61 nM) independently of Bcl-2 and Bcl-xL.2,3 In vivo, ATN-224 (0.7 mg/kg) chelates copper to stabilize an antitumor viral vector, enhancing its efficacy against lung metastases in mice.4 It also inhibits angiogenesis in a mouse model (IC50s = 1.50-3 mg/kg via gavage).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Doñate, F., Juarez, J.C., Burnett, M.E., et al. Identification of biomarkers for the antiangiogenic and antitumour activity of the superoxide dismutase 1 (SOD1) inhibitor tetrathiomolybdate (ATN-224). Br. J. Cancer 98(4), 776-783 (2008).

    2. Lee, K., Briehl, M.M., Mazar, A.P., et al. The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies. Free Radic. Biol. Med. 60, 157-167 (2013).

    3. Lee, K., Hart, M.R., Briehl, M.M., et al. The copper chelator ATN-224 induces caspase-independent cell death in diffuse large B cell lymphoma. Int. J. Oncol. 45(1), 439-447 (2014).

    4. Yoo, J.Y., Yu, J.G., Kaka, A., et al. ATN-224 enhances antitumor efficacy of oncolytic herpes virus against both local and metastatic head and neck squamous cell carcinoma. Mol. Ther. Oncolytics 2, 15008 (2015).

    Product Citations

    Biyashev, D., Siwicka, Z.E., Onay, U.V., et al. Topical application of synthetic melanin promotes tissue repair. NPJ Regen. Med. 8(1), 61 (2023).