A partial agonist of GABAB receptors
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

3-Aminopropylphosphonic Acid

Item No. 23556

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
P-(3-aminopropyl)-phosphonic acid
CAS Number
13138-33-5
Synonyms
  • β-Aminopropylphosphonic Acid
  • 3-APPA
  • NSC 133832
Molecular Formula
C3H10NO3P
Formula Weight
139.1
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
NCCCP(O)(O)=O
InChi Code
InChI=1S/C3H10NO3P/c4-2-1-3-8(5,6)7/h1-4H2,(H2,5,6,7)
InChi Key
GSZQTIFGANBTNF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    100 mg

    $69

    Add

    250 mg

    $132

    Add

    500 mg

    $214

    Add
    Product Description

    3-Aminopropylphosphonic acid (3-APPA) is a phosphonic analog of GABA that acts as a partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding assay).1,2 It induces relaxation in unstimulated isolated guinea pig ileum longitudinal muscle and reverses GABA- and baclofen-induced inhibition of twitch responses in isolated guinea pig ileum longitudinal muscle.1 3-APPA (5 mg/kg) completely inhibits GABA- and baclofen-induced inhibition of vagally stimulated bronchospasms in guinea pigs.3 It also reverses the antitussive effect of baclofen in cats when administered at a dose of 3 mg/kg.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Luzzi, S., Franchi-Micheli, S., Ciuffi, M., et al. GABA-related activities of amino phosphonic acids on guinea-pig ileum longitudinal muscle. J. Auton. Pharmacol. 6(3), 163-169 (1986).

    2. Ling, Q., Xu, X., Wei, X., et al. Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome c. J. Exp. Clin. Cancer Res. 30, 66 (2011).

    3. Chapman, R.W., Danko, G., Rizzo, C., et al. Prejunctional GABA-B inhibition of cholinergic, neurally-mediated airway contractions in guinea-pigs. Pulm. Pharmacol. 4(4), 218-224 (1991).

    4. Bolser, D.C., Aziz, S.M., DeGennaro, F.C., et al. Antitussive effects of GABAB agonists in the cat and guinea-pig. Br. J. Pharmacol. 110(1), 491-495 (1993).