Active • Host: E. coli • AA: 138-379 • Tag: N-terminal His • MW: 28.8 kDa
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STING M284 variant (human, recombinant)

Item No. 23594

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Endoplasmic Reticulum Interferon Stimulator
  • ERIS
  • hSTING
  • MITA
  • Stimulator of Interferon Genes Protein
  • TMEM173
  • Transmembrane Protein 173
Purity
≥80% estimated by SDS-PAGE
Source
N-terminal His-tagged human recombinant protein expressed in E. coli
Amino Acids
138-379 (N-terminal truncation)
MW
28.8 kDa
Formulation (Request formulation change)
50 mM HEPES, pH 8.0 with 150 mM sodium chloride and 10% glycerol
UniProt Accession №
Q86WV6
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    100 µg

    $649

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    Product Description

    STING M284 variant (human, recombinant) contains amino acids 138-379 of the wild-type variant (R232) with a methionine substituted for arginine at position 284. Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-κB and transcription of immunomodulatory genes, including type I interferon (IFN).1,2,3,4 The R232 variant of STING is the most common variant in the human population, found at a frequency of 57.9% in the 1000 Genome Project.5 The SNP variant H232 is found at a 13.7% frequency. The R284M mutation in STING is associated with constitutive activation of downstream signaling. It increases the propensity of STING to dimerize and associate with the kinase TBK1, enhancing the ability of STING to activate IRF3 and NF-κB and induce a type I IFN response.6 However, the R284M mutation occurs outside of the dimerization region between positions 153-177, so rather than a direct effect on dimerization, it is predicted to promote or inhibit binding of a cellular factor that stabilizes or impairs STING dimerization.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sun, L., Wu, J., Du, F., et al. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339(6121), 786-791 (2013).

    2. Wu, J., Sun, L., Chen, X., et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 339(6121), 826-830 (2013).

    3. Konno, H., Konno, K., and Barber, G.N. Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling. Cell 155(3), 688-698 (2013).

    4. Burdette, D.L., Monroe, K.M., Sotelo-Troha, K., et al. STING is a direct innate immune sensor of cyclic-di-GMP. Nature 478(7370), 515-518 (2011).

    5. Yi, G., Brendel, V.P., Shu, C., et al. Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotides. PLoS One 8(10), e77846 (2013).

    6. Tang, E.D., and Wang, C.-Y. Single amino acid change in STING leads to constitutive active signaling. PLoS One 10(3), e0120090 (2015).