A cephamycin antibiotic
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Cefotetan (sodium salt)

Item No. 23624

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6R,7S)-7-[[[4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, disodium salt
CAS Number
74356-00-6
Synonyms
  • YM-09330
Molecular Formula
C17H15N7O8S4 • 2Na
Formula Weight
619.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
290 nm
SMILES
O=C(N[C@@]1(OC)[C@](SCC(CSC2=NN=NN2C)=C3C([O-])=O)([H])N3C1=O)C4S/C(S4)=C(C([O-])=O)\C(N)=O.[Na+].[Na+]
InChi Code
InChI=1S/C17H17N7O8S4.2Na/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28;;/h13,15H,3-4H2,1-2H3,(H2,18,25)(H,19,26)(H,27,28)(H,29,30);;/q;2*+1/p-2/b12-6-;;/t13?,15-,17+;;/m1../s1
InChi Key
ZQQALMSFFARWPK-GLHLDKNHSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Cefotetan is a cephamycin antibiotic that is active against both Gram-positive and Gram-negative bacteria including isolates of E. coli, S. aureus, K. pneumoniae, and P. maltophilia (MICs = 0.03-32 mg/ml).1 It reduces mortality by 50% in a rabbit model of fecal peritonitis when administered at a dose of 25 mg/kg twice daily.2 Formulations containing cefotetan have been used in the treatment of various bacterial infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Daschner, F.D., Goerke, C., Bassler, M., et al. In vitro comparison of cefotetan with five other cephalosporins against nosocomial pathogens. Chemotherapy 28(5), 351-354 (1982).

    2. Ablan, C.J., Olen, R.N., Dobrin, P.B., et al. Efficacy of intraperitoneal antibiotics in the treatment of severe fecal peritonitis. Am. J. Surg. 162(5), 453-456 (1991).