A cephalosporin antibiotic
Related Products
Labeled Version(s)
31163Cefuroxime-d3
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Cefuroxime (sodium salt)

Item No. 23627

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6R,7R)-3-[[(aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-(2-furanyl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monosodium salt
CAS Number
56238-63-2
Molecular Formula
C16H15N4O8S • Na
Formula Weight
446.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly SolubleMethanol: Slightly Soluble
SMILES
O=C([O-])C1=C(COC(N)=O)CS[C@@]([C@@H]2NC(/C(C3=CC=CO3)=N\OC)=O)([H])N1C2=O.[Na+]
InChi Code
InChI=1S/C16H16N4O8S.Na/c1-26-19-9(8-3-2-4-27-8)12(21)18-10-13(22)20-11(15(23)24)7(5-28-16(17)25)6-29-14(10)20;/h2-4,10,14H,5-6H2,1H3,(H2,17,25)(H,18,21)(H,23,24);/q;+1/p-1/b19-9-;/t10-,14-;/m1./s1
InChi Key
URDOHUPGIOGTKV-JTBFTWTJSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 mg

    $75

    Add

    1 g

    $120

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    Cefuroxime is a cephalosporin antibiotic with broad-spectrum activity against Gram-positive and Gram-negative bacteria including S. pyogenes, S. pneumoniae, S. viridans, E. coli, P. mirabilis, H. influenzae, and N. gonorrhoeae (mean MICs = 0.005-8.2 μg/ml).1 Like other cephalosporins, cefuroxime inhibits peptidoglycan crosslinking and bacterial cell wall synthesis.2 It is resistant to hydrolysis by bacterial β-lactamases, increasing its efficacy against β-lactamase producing Gram-negative bacteria.3 Cefuroxime is protective against Gram-positive and Gram-negative infections in vivo with mean ED50 values ranging from 2 to 35 and 1 to 55 mg/kg, in mice and rats, respectively.4 Formulations containing cefuroxime have been used to treat urinary tract infections.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. O'Callaghan, C.H., Sykes, R.B., Griffiths, A., et al. Cefuroxime, a new cephalosporin antibiotic: Activity in vitro. Antimicrob. Agents Chemother. 9(3), 511-519 (1976).

    2. Curtis, N.A.C., Hughes, J.M., and Ross, G.W. Inhibition of peptidoglycan cross-linking in growing cells of Escherichia coli by penicillins and cephalosporins, and its prevention by R factor-mediated beta-lactamase. Antimicrob. Agents Chemother. 9(2), 208-213 (1976).

    3. Richmond, M.H., and Wotton, S. Comparative study of seven cephalosporins: Susceptibility to beta-lactamases and ability to penetrate the surface layers of Escherichia coli. Antimicrob. Agents Chemother. 10(2), 219-222 (1976).

    4. Ryan, D.M., O'Callaghan, C.H., and Muggleton, P.W. Cefuroxime, a new cephalosporin antibiotic: Activity in vivo. Antimicrob. Agents Chemother. 9(3), 520-525 (1976).

    5. Masika, W.G., O'Meara, W.P., Holland, T.L., et al. Contribution of urinary tract infection to the burden of febrile illnesses in young children in rural Kenya. PLoS One 12(3), e0174199 (2017).