An aminoglycoside antibiotic
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Paromomycin (sulfate)

Item No. 23634

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-D-streptamine, sulfate
CAS Number
1263-89-4
Molecular Formula
C23H45N5O14 • XH2SO4
Formula Weight
615.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
OC[C@H]1O[C@H](O[C@@]2([H])[C@H](O[C@]3([H])O[C@H](CO)[C@@H](O[C@]4([H])[C@H](N)[C@@H](O)[C@H](O)[C@H](CN)O4)[C@H]3O)[C@@H](O)[C@H](N)C[C@@H]2N)[C@H](N)[C@@H](O)[C@@H]1O.O=S(O)(O)=O
InChi Code
InChI=1S/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1
InChi Key
LJRDOKAZOAKLDU-UDXJMMFXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Paromomycin is an aminoglycoside antibiotic that is effective against Gram-negative and Gram-positive bacteria (MICs = 0.08-3.9 µg/ml).1 It also has antiprotozoal properties and decreases the parasite burden of mice infected with the leishmanial strain L. tropica when administered at doses of 50 mg/kg and 15 mg/kg, through intramuscular or intralesional routes, respectively.2 Paromomycin binds to the tRNA decoding A site of the 16S ribosomal RNA in bacteria, inducing a conformational change that disrupts translation and inhibits protein synthesis.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Taniyama, H., Sawada, Y., and Tanaka, S. Antibiotics aminosidin. II. Some amino derivatives of aminosidin and their biological activity. Chem. Pharm. Bull. (Tokyo) 21(3), 609-615 (1973).

    2. Heidari-Kharaji, M., Taheri, T., Doroud, D., et al. Solid lipid nanoparticle loaded with paromomycin: In vivo efficacy against Leishmania tropica infection in BALB/c mice model. Appl. Microbiol. Biotechnol. 100(16), 7051-7060 (2016).

    3. Vicens, Q., and Westhof, E. Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site. Structure 9(8), 647-658 (2001).