A depsidone with antibacterial activity
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Nornidulin

Item No. 23646

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,4,7-trichloro-3,8-dihydroxy-1,9-dimethyl-6-(1-methyl-1-propen-1-yl)-11H-dibenzo[b,e][1,4]dioxepin-11-one
CAS Number
33403-37-1
Molecular Formula
C19H15Cl3O5
Formula Weight
429.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
CC1=C(O)C(Cl)=C(/C(C)=C\C)C2=C1OC(C3=C(C(Cl)=C(O)C(Cl)=C3C)O2)=O
InChi Code
InChI=1S/C19H15Cl3O5/c1-5-6(2)9-12(21)14(23)8(4)16-18(9)26-17-10(19(25)27-16)7(3)11(20)15(24)13(17)22/h5,23-24H,1-4H3/b6-5-
InChi Key
XEQDVQKKHOQZEP-WAYWQWQTSA-N
Origin
Fungus/Emericella sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $248

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    5 mg

    $1,052

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    Cayman Chemical
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    Product Description

    Nornidulin is a depsidone originally isolated from A. nidulans that has antibacterial activity against M. tuberculosis and M. ranoe as well as antifungal activity against T. tonsurans and M. audouini.1 It also inhibits the growth of methicillin-resistant S. aureus (MRSA; MIC = 2 µg/ml).2 Nornidulin has cytotoxic activity in MOLT-3 cells (IC50 = 35.7 µM) but not HuCCA-1, HepG2, or A549 cells (IC50s = >116.4 µM).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dean, F.M., Roberston, A., Roberts, J.C., et al. Nidulin and “Ustin”: Two chlorine-containing metabolic products of Aspergillus nidulans. Nature 172(4372), 344 (1953).

    2. Zhang, Y., Mu, J., Feng, Y., et al. Four chlorinated depsidones from a seaweed-derived strain of Aspergillus unguis and their new biological activities. Nat. Prod. Res. 28(7), 503-506 (2014).

    3. Sureram, S., Wiyakrutta, S., Ngamrojanavanich, N., et al. Depsidones, aromatase inhibitors and radical scavenging agents from the marine-derived fungus Aspergillus unguis CRI282-03. Planta Med. 78(6), 582-588 (2012).