Thiothixene

Thiothixene is a typical antipsychotic.¹ It selectively binds to dopamine D₂ over D₁, D₃, and D₄ receptors (K_is = 0.417, 338, 186.2, and 363.1 nM, respectively). Thiothixene also binds to various serotonin (5-HT), histamine H₁, α₁- and α₂-adrenergic, muscarinic acetylcholine, and sigma receptors (K_is = 15-5,754 nM) as well as the dopamine, norepinephrine, and serotonin transporters (K_is = 3.16-30 μM). In vivo, thiothixene reduces spontaneous and amphetamine-induced locomotor activity in rats.² It enhances latent inhibition, as measured by a decreased lick latency in response to light and foot shock stimuli, which is a measure of selective attention in rats.³ Thiothixene also increases competitive behavior in submissive mice, indicating antidepressant-like behavior.⁴ Formulations containing thiothixene have been used in the treatment of schizophrenia and bipolar mania.

WARNING This product is not for human or veterinary use.

1. Silvestre, J.S., and Prous, J. Research on adverse drug events. I. Muscarinic M3 receptor binding affinity could predict the risk of antipsychotics to induce type 2 diabetes. Methods Find. Exp. Clin. Pharmacol. 27(5), 289-304 (2005).

2. Schaefer, G.J., and Michael, R.P. Drug interactions on spontaneous locomotor activity in rats. Neuroleptics and amphetamine-induced hyperactivity. Neuropharmacology 23(8), 909-914 (1984).

3. Dunn, L.A., Atwater, G.E., and Kilts, C.D. Effects of antipsychotic drugs on latent inhibition: Sensitivity and specificity of an animal behavioral model of clinical drug action. Psychopharmacology (Berl.) 112(2-3), 315-323 (1993).

4. Malatynska, E., Rapp, R., Harrawood, D., et al. Submissive behavior in mice as a test for antidepressant drug activity. Pharmacol. Biochem. Behav. 82(2), 306-313 (2005).