A NSAID and COX-2 inhibitor
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Labeled Version(s)
31788Mefenamic Acid-d4
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Mefenamic Acid

Item No. 23650

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(2,3-dimethylphenyl)amino]-benzoic acid
CAS Number
61-68-7
Synonyms
  • C.I. 473
  • CN 35355
  • NSC 94437
Molecular Formula
C15H15NO2
Formula Weight
241.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly SolubleMethanol: Slightly Soluble
SMILES
CC1=CC=CC(NC2=CC=CC=C2C(O)=O)=C1C
InChi Code
InChI=1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18)
InChi Key
HYYBABOKPJLUIN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $53

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    50 mg

    $98

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    100 mg

    $185

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    500 mg

    $763

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    Product Description

    Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and a COX-2 inhibitor.1 It binds to COX-2 (Kd = 4 nM) and inhibits COX-2-dependent oxygenation of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in vitro (Ki = 10 µM). Mefenamic acid (30 mg/kg) reduces acetic acid-induced writhing in rats.2 It inhibits increases in skin thickness in a mouse model of delayed-type hypersensitivity induced by dinitrochlorobenzene (DNBC).2 Mefenamic acid also reduces the antibody response to sheep red blood cells in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Prusakiewicz, J.J., Duggan, K.C., Rouzer, C.A., et al. Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid. Biochemistry 48(31), 7353-7355 (2009).

    2. Roszkowski, A.P., Rooks, W.H., Tomolonis, A.J., et al. Anti-inflammatory and analgetic properties of d-2-(6'-methoxy-2'-naphthyl)-propionic acid (naproxen). J. Pharmacol. Exp. Ther. 179(1), 114-123 (1971).