A synthetic corticosteroid
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Prednicarbate

Item No. 23668

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(11β)-17-[(ethoxycarbonyl)oxy]-11-hydroxy-21-(1-oxopropoxy)-pregna-1,4-diene-3,20-dione
CAS Number
73771-04-7
Synonyms
  • Prednisolone 17-(ethyl carbonate) 21-propionate
  • S 77-0777
Molecular Formula
C27H36O8
Formula Weight
488.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly SolubleEthanol: Slightly SolubleMethanol: Slightly Soluble
SMILES
[H][C@]12[C@@]([C@@](CC[C@]3(OC(OCC)=O)C(COC(CC)=O)=O)([H])[C@]3(C)C[C@@H]2O)([H])CCC4=CC(C=C[C@@]41C)=O
InChi Code
InChI=1S/C27H36O8/c1-5-22(31)34-15-21(30)27(35-24(32)33-6-2)12-10-19-18-8-7-16-13-17(28)9-11-25(16,3)23(18)20(29)14-26(19,27)4/h9,11,13,18-20,23,29H,5-8,10,12,14-15H2,1-4H3/t18-,19-,20-,23+,25-,26-,27-/m0/s1
InChi Key
FNPXMHRZILFCKX-KAJVQRHHSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Product Description

    Prednicarbate is a synthetic corticosteroid and a derivative of prednisolone (Item No. 20866).1 It has anti-inflammatory activity comparable to that of desoximetasone in various murine models when administered topically but lacks activity when administered subcutaneously. Topical administration of prednicarbate (2 drops of a 0.1% solution per day) induces wound healing in hairless mice.2 Formulations containing prednicarbate have been used to treat chronic hand eczema.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Alpermann, H.G., Sandow, J., and Vogel, H.G. Animal experiment studies on the topical and systemic effectiveness of prednisolone-17-ethylcarbonate-21-propionate. Z. Hautkr. 61(1), 7-17 (1986).

    2. Bodor, N.S., Kiss-Buris, S.T., and Buris, L. Novel soft steroids: Effects on cell growth in vitro and on wound healing in the mouse. Steroids 56(8), 434-439 (1991).

    3. Soost, S., Abdollahnia, M., Kostev, K., et al. Topical therapy of hand eczema - analysis of the prescription profile from dermatologists in private practice. J. Dtsch. Dermatol. Ges. 10(3), 180-184 (2012).