An NSAID
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Labeled Version(s)
30745Etofenamate-d4
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Etofenamate

Item No. 23674

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[3-(trifluoromethyl)phenyl]amino]-benzoic acid, 2-(2-hydroxyethoxy)ethyl ester
CAS Number
30544-47-9
Molecular Formula
C18H18F3NO4
Formula Weight
369.3
Purity
≥98%
Formulation
A neat oil
Solubility(Learn about Variance in Solubility)
DMF: 40 mg/mlDMSO: 40 mg/mlEthanol: 50 mg/mlEthanol:PBS(pH 7.2) (1:5): 0.1 mg/ml
λmax
205, 221, 287, 347 nm
SMILES
O=C(OCCOCCO)C1=C(NC2=CC=CC(C(F)(F)F)=C2)C=CC=C1
InChi Code
InChI=1S/C18H18F3NO4/c19-18(20,21)13-4-3-5-14(12-13)22-16-7-2-1-6-15(16)17(24)26-11-10-25-9-8-23/h1-7,12,22-23H,8-11H2
InChi Key
XILVEPYQJIOVNB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    50 mg

    $98

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    100 mg

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    250 mg

    $291

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    500 mg

    $530

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    Product Description

    Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) and diethylene glycol ester form of flufenamic acid (Item No. 21447) that has anti-inflammatory and analgesic activities.1,2 It inhibits lipoxygenase isolated from guinea pig leukocytes (IC50 = 5.3 μM) and the production of prostaglandin E2 (PGE2; Item No. 14010) in stimulated rat peritoneal macrophages.2 In vivo, etofenamate reduces acetic acid-induced vascular permeability in mice and UV-induced erythema in guinea pigs in a dose-dependent manner at doses ranging from 40-320 and 5-20 mg/kg, respectively.1 Etofenamate (40 mg/kg per day for 21 days) inhibits inflammation in a rat model of adjuvant-induced arthritis. It also decreases the pain response in a silver nitrate-induced rat model of arthritis and the acetic acid-induced writhing test in mice, indicating analgesic activity. Formulations containing etofenamate have been used in the treatment of osteoarthritis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nakamura, H., Motoyoshi, S., Imazu, C., et al. Anti-inflammatory, analgesic and anti-pyretic activities of a non-steroidal anti-inflammatory drug, etofenamate, in experimental animals. Nihon Yakurigaku Zasshi. 80(2), 125-135 (1982).

    2. Nakamura, H., Motoyoshi, S., Ishii, K., et al. The mode of anti-inflammatory action of a topical non-steroidal anti-inflammatory drug, etofenamate. Nihon Yakurigaku Zasshi. 89(1), 15-24 (1987).