A URAT1 inhibitor
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Lesinurad

Item No. 23688

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[5-bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-acetic acid
CAS Number
878672-00-5
Molecular Formula
C17H14BrN3O2S
Formula Weight
404.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly SolubleMethanol: Slightly Soluble
SMILES
BrC1=NN=C(SCC(O)=O)N1C2=C3C(C=CC=C3)=C(C4CC4)C=C2
InChi Code
InChI=1S/C17H14BrN3O2S/c18-16-19-20-17(24-9-15(22)23)21(16)14-8-7-11(10-5-6-10)12-3-1-2-4-13(12)14/h1-4,7-8,10H,5-6,9H2,(H,22,23)
InChi Key
FGQFOYHRJSUHMR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $63

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    10 mg

    $105

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    25 mg

    $229

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    50 mg

    $392

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    Product Description

    Lesinurad is an inhibitor of urate anion transporter 1 (URAT1; IC50s = 3.5 and 81 µM for human and rat transporters, respectively), a transporter that prevents renal urate resorption.1 It decreases uptake of urate by MDCK cells transfected with human URAT1.2 Lesinurad (80 mg/kg) also decreases serum levels of uric acid and urea nitrogen in a rat model of gout. Formulations containing lesinurad have been used in combination with other compounds in the treatment of gout.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tan, P.K., Ostertag, T.M., and Miner, J.N. Mechanism of high affinity inhibition of the human urate transporter URAT1. Sci. Rep. 6:34995, (2016).

    2. Wu, T., Chen, J., Dong, S., et al. Identification and characterization of a potent and selective inhibitor of human urate transporter 1. Pharmacol. Rep. (2017).