An antimycobacterial compound
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Ethambutol (hydrochloride)

Item No. 23713

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2S,2'S-(1,2-ethanediyldiimino)bis-1-butanol, dihydrochloride
CAS Number
1070-11-7
Molecular Formula
C10H24N2O2 • 2HCl
Formula Weight
277.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly solubleWater: Slightly soluble
SMILES
CC[C@H](NCCN[C@H](CO)CC)CO.Cl.Cl
InChi Code
InChI=1S/C10H24N2O2.2ClH/c1-3-9(7-13)11-5-6-12-10(4-2)8-14;;/h9-14H,3-8H2,1-2H3;2*1H/t9-,10-;;/m0../s1
InChi Key
AUAHHJJRFHRVPV-BZDVOYDHSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

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    Cayman Chemical
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    Product Description

    Ethambutol is an antimycobacterial compound that inhibits the growth of M. tuberculosis in vitro at a concentration of 10 μg/ml.1 It is protective against M. smegmatis infections in rhesus monkeys (50, 30, and 0% fatalities at doses of 12.5, 25, and 50 mg/kg, respectively) and clears M. smegmatis pulmonary infiltrates at a dose of 100 mg/kg.2 Formulations containing ethambutol have been used in the treatment of tuberculosis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dickinson, J.M., and Mitchison, D.A. In vitro and in vivo studies to assess the suitability of anti-tuberculous drugs for use in intermittent chemotherapy regimens. Bull. Int. Union. Tuberc. 41(S1), 309-315 (1968).

    2. Schmidt, L.H. Studies on the antituberculous activity of ethambutol in monkey. Ann. N. Y. Acad. Sci. 135(2), 747-758 (1966).