An inhibitor of plasmin activating enzymes
Related Products
Isomer(s)
41562Isoleucine
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

6-Aminocaproic Acid

Item No. 23724

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-amino-hexanoic acid
CAS Number
60-32-2
Synonyms
  • ε-Aminocaproic Acid
  • EACA
  • NSC 26154
  • NSC 212532
  • NSC 400230
Molecular Formula
C6H13NO2
Formula Weight
131.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
202 nm
SMILES
OC(CCCCCN)=O
InChi Code
InChI=1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)
InChi Key
SLXKOJJOQWFEFD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 g

    $63

    Add

    100 g

    $110

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    6-Aminocaproic acid is an inhibitor of the plasmin activating enzymes streptokinase, fibrinokinase, and urokinase (IC50s = ~8 μM for all in an enzyme assay).1 It is selective for plasmin activating enzymes over trypsin (IC50 = >500 μM). 6-Aminocaproic acid inhibits in vitro plasmin activation and fibrinolysis in a dose-dependent manner. Ex vivo, 6-aminocaproic acid reduces fibrinolysis in dog plasma following i.p. administration at doses ranging from 20-100 mg/kg.2 Formulations containing 6-aminocaproic acid have been used to decrease postoperative blood transfusion rates following knee surgery.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Alkjaersig, N., Fletcher, A.P., and Sherry, S. ɛ-Aminocaproic acid: An inhibitor of plasminogen activation. The Journal of Biological Chemisty 234(4), 832-837 (1959).

    2. Brown, J.C., Brainard, B.M., Fletcher, D.J., et al. Effect of aminocaproic acid on clot strength and clot lysis of canine blood determined by use of an in vitro model of hyperfibrinolysis. Am. J. Vet. Res. 77(11), 1258-1265 (2016).

    3. Churchill, J.L., Puca, K.E., Meyer, E., et al. Comparing ε-aminocaproic acid and tranexamic acid in reducing postoperative transfusions in total knee arthroplasty. J. Knee Surg. 30(5), 460-466 (2017).