An inhibitor of plasmin activating enzymes
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6-Aminocaproic Acid

Item No. 23724

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-amino-hexanoic acid
CAS Number
60-32-2
Synonyms
  • ε-Aminocaproic Acid
  • EACA
  • NSC 26154
  • NSC 212532
  • NSC 400230
Molecular Formula
C6H13NO2
Formula Weight
131.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
202 nm
SMILES
OC(CCCCCN)=O
InChi Code
InChI=1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)
InChi Key
SLXKOJJOQWFEFD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    6-Aminocaproic acid is an inhibitor of the plasmin activating enzymes streptokinase, fibrinokinase, and urokinase (IC50s = ~8 μM for all in an enzyme assay).1 It is selective for plasmin activating enzymes over trypsin (IC50 = >500 μM). 6-Aminocaproic acid inhibits in vitro plasmin activation and fibrinolysis in a dose-dependent manner. Ex vivo, 6-aminocaproic acid reduces fibrinolysis in dog plasma following i.p. administration at doses ranging from 20-100 mg/kg.2 Formulations containing 6-aminocaproic acid have been used to decrease postoperative blood transfusion rates following knee surgery.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Alkjaersig, N., Fletcher, A.P., and Sherry, S. ɛ-Aminocaproic acid: An inhibitor of plasminogen activation. The Journal of Biological Chemisty 234(4), 832-837 (1959).

    2. Brown, J.C., Brainard, B.M., Fletcher, D.J., et al. Effect of aminocaproic acid on clot strength and clot lysis of canine blood determined by use of an in vitro model of hyperfibrinolysis. Am. J. Vet. Res. 77(11), 1258-1265 (2016).

    3. Churchill, J.L., Puca, K.E., Meyer, E., et al. Comparing ε-aminocaproic acid and tranexamic acid in reducing postoperative transfusions in total knee arthroplasty. J. Knee Surg. 30(5), 460-466 (2017).