An inhibitor of influenza neuraminidase
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Peramivir

Item No. 23765

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1S,2S,3R,4R)-3-[(1S)-1-(acetylamino)-2-ethylbutyl]-4-[(aminoiminomethyl)amino]-2-hydroxy-cyclopentanecarboxylic acid
CAS Number
330600-85-6
Synonyms
  • BCX 1812
  • RWJ 270201
Molecular Formula
C15H28N4O4
Formula Weight
328.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
SMILES
OC([C@H]1C[C@@H](NC(N)=N)[C@@]([C@@H](NC(C)=O)C(CC)CC)([H])[C@@H]1O)=O
InChi Code
InChI=1S/C15H28N4O4/c1-4-8(5-2)12(18-7(3)20)11-10(19-15(16)17)6-9(13(11)21)14(22)23/h8-13,21H,4-6H2,1-3H3,(H,18,20)(H,22,23)(H4,16,17,19)/t9-,10+,11+,12-,13+/m0/s1
InChi Key
XRQDFNLINLXZLB-CKIKVBCHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Peramivir is an inhibitor of influenza neuraminidase (IC50s = 0.09 and 11 nM for influenza A and B neuraminidases, respectively).1 It is selective for influenza neuraminidase over bacterial, mammalian, and other viral neuraminidases (IC50s = >300 μM). Peramivir inhibits neuraminidase activity in H1N1, H2N2, H3N2, and H6N2 influenza strains (IC50s = 0.09-1.1 nM) and reduces lysis of MDCK cells infected with influenza (EC50s = <0.01-21 nM). Pretreatment with peramivir (10-100 mg/kg) protects mice against lethal influenza infections. It also increases survival in ferrets infected intranasally with avian influenza type A H5N1 when injected intramuscularly after infection.2 Formulations containing peramivir have been used to treat influenza.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Young, D., Fowler, C., and Bush, K. RWJ-270201 (BCX-1812): A novel neuraminidase inhibitor for influenza. Philos. Trans. R. Soc. Lond. B Biol. Sci 356(1416), 1905-1913 (2001).

    2. Yun, N.E., Linde, N.S., Zacks, M.A., et al. Injectable peramivir mitigates disease and promotes survival in ferrets and mice infected with the highly virulent influenza virus, A/Vietnam/1203/04 (H5N1). Virology 374(1), 198-209 (2008).