A semisynthetic penicillin antibiotic
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Dicloxacillin (sodium salt hydrate)

Item No. 23770

Technical Information
Formal Name
(2S,5R,6R)-6-[[[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, monosodium salt, monohydrate
CAS Number
13412-64-1
Molecular Formula
C19H16Cl2N3O5S • Na [H2O]
Formula Weight
Purity
≥98%
A crystalline solid
DMF: 33 mg/mlDMSO: 33 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
CC1(C)[C@H](C([O-])=O)N2C([C@@H](NC(C3=C(C)ON=C3C4=C(Cl)C=CC=C4Cl)=O)[C@@]2([H])S1)=O.[Na+].O
InChi Code
InChI=1S/C19H17Cl2N3O5S.Na.H2O/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24;;/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28);;1H2/q;+1;/p-1/t13-,14+,17-;;/m1../s1
InChi Key
SIGZQNJITOWQEF-VICXVTCVSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Dicloxacillin is a semisynthetic penicillin antibiotic that has activity against Gram-positive bacteria (MICs = 0.02-0.24 μg/ml for S. pyogenes, S. aureus, and D. pneumoniae).1 Dicloxacillin is protective against S. pyogenes, S. aureus, and D. pneumoniae infections in mice when administered subcutaneously or orally (PD50s = 12-185 and 41-280 mg/kg, respectively). Formulations containing dicloxacillin have been used prophylactically during catheterization and in dog bite patients.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Miraglia, G.J., and Basch, H.I. Activity of selected penicillins in vitro and in experimental bacterial infections in mice. Appl. Microbiol. 15(3), 566-568 (1967).