A synthetic glucocorticoid
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Difluprednate

Item No. 23776

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
21-(acetyloxy)-6α,9-difluoro-11β-hydroxy-17-(1-oxobutoxy)-pregna-1,4-diene-3,20-dione
CAS Number
23674-86-4
Synonyms
  • W-6309
Molecular Formula
C27H34F2O7
Formula Weight
508.6
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.33 mg/mlEthanol: 1 mg/ml
λmax
238 nm
SMILES
O=C1C=C[C@@]2(C)C([C@@H](F)C[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(OC(CCC)=O)C(COC(C)=O)=O)=C1
InChi Code
InChI=1S/C27H34F2O7/c1-5-6-23(34)36-26(22(33)14-35-15(2)30)10-8-17-18-12-20(28)19-11-16(31)7-9-24(19,3)27(18,29)21(32)13-25(17,26)4/h7,9,11,17-18,20-21,32H,5-6,8,10,12-14H2,1-4H3/t17-,18-,20-,21-,24-,25-,26-,27-/m0/s1
InChi Key
WYQPLTPSGFELIB-JTQPXKBDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $38

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    25 mg

    $79

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    50 mg

    $129

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    Product Description

    Difluprednate is a synthetic glucocorticoid that potently activates the glucocorticoid receptor (Ki = 78 pM).1 In vivo, ocular administration of difluprednate (0.05% w/v) increases intraocular pressure in sheep.2 Formulations containing difluprednate have been used to treat diabetic macular edema and inflammation following cataract surgery.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tajika, T., Waki, M., Tsuzuki, M., et al. Pharmacokinetic features of difluprednate ophthalmic emulsion in rabbits as determined by glucocorticoid receptor-binding bioassay. J. Ocul. Pharmacol. Ther. 27(1), 29-34 (2011).

    2. Borrás, T., Buie, L.K., and Spiga, M.G. Inducible scAAV2.GRE.MMP1 lowers IOP long-term in a large animal model for steroid-induced glaucoma gene therapy. Gene Ther. 23(5), 438-449 (2016).