A synthetic glucocorticoid
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Halobetasol Propionate

Item No. 23781

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
21-chloro-6α,9-difluoro-11β-hydroxy-16β-methyl-17-(1-oxopropoxy)-pregna-1,4-diene-3,20-dione
CAS Number
66852-54-8
Synonyms
  • BMY 30056
  • CGP 14458
Molecular Formula
C25H31ClF2O5
Formula Weight
485.0
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly SolubleMethanol: Slightly Soluble
SMILES
O=C1C=C[C@@]2(C)C([C@@H](F)C[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@H](C)[C@@]4(C(CCl)=O)OC(CC)=O)=C1
InChi Code
InChI=1S/C25H31ClF2O5/c1-5-21(32)33-25(20(31)12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15-,16-,18-,19-,22-,23-,24-,25-/m0/s1
InChi Key
BDSYKGHYMJNPAB-LICBFIPMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

    $36

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    10 mg

    $61

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    25 mg

    $128

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    50 mg

    $186

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    Product Description

    Halobetasol propionate is a synthetic glucocorticoid.1 It inhibits dermatitis induced by ultraviolet light in guinea pigs (ED50 = 1.45 µg/animal) and by oxazolone in mice (ED50 = 0.8 µg/animal).2 Halobetasol propionate also has anti-inflammatory effects on croton oil-induced ear edema in rats (ED50s = 10 µg/ml and 0.5 µg/ear) and mice (ED50s = 1.2 and <0.32 µg/ear after 6 and 24 hours of treatment, respectively). Topical formulations containing halobetasol propionate have been used for inflammatory and pruritic dermatitis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Avery, A.M., and Chittiboyina, A.G. Anti‐inflammatory glucocorticoids. Burger's medicinal chemistry, drug discovery and development 7, 35-152 (2010).

    2. Yawalkar, S., Wiesenberg-Boettcher, I., Gibson, J.R., et al. Dermatopharmacologic investigations of halobetasol propionate in comparison with clobetasol 17-propionate. J. Am. Acad. Dermatol. 25(6), 1137-1144 (1991).