A sodium channel blocker and class Ib antiarrhythmic agent
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Mexiletine (hydrochloride)

Item No. 23782

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(2,6-dimethylphenoxy)-2-propanamine, monohydrochloride
CAS Number
5370-01-4
Synonyms
  • Ko 1173
Molecular Formula
C11H17NO • HCl
Formula Weight
215.7
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mLDMSO: 10 mg/mLEthanol: 30 mg/mLPBS (pH 7.2): 10 mg/mL
SMILES
CC1=CC=CC(C)=C1OCC(C)N.Cl
InChi Code
InChI=1S/C11H17NO.ClH/c1-8-5-4-6-9(2)11(8)13-7-10(3)12;/h4-6,10H,7,12H2,1-3H3;1H
InChi Key
NFEIBWMZVIVJLQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $36

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    10 g

    $68

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    Product Description

    Mexiletine is a voltage-gated sodium channel blocker and class Ib antiarrhythmic agent that preferentially binds to open/inactive channels.1 It inhibits aconitine-induced dysrhythmias in mice with ED50 values of 57 and 107 mg/kg for intraperitoneal and oral administration, respectively.2 Mexiletine decreases or inhibits conduction across the Purkinje fiber-muscle junction, shortens action potential duration, and decreases the refractory period when used at concentrations less than 5 µg/ml in isolated canine Purkinje fiber and ventricular muscle preparations.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Roselli, M., Carocci, A., Budriesi, R., et al. Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues. Eur. J. Med. Chem. 121(1), 300-307 (2016).

    2. Winslow, E. Evaluation of antagonism of aconitine-induced dysrhythmias in mice as a method of detecting and assessing antidysrhythmic activity. Br. J. Pharmacol. 71(2), 615-622 (1980).

    3. Iwamura, N., Shimizu, T., Toyoshima, H., et al. Electrophysiological actions of a new antiarrhythmic agent on isolated preparations of the canine purkinje fiber and ventricular muscle. Cardiology 61(5-6), 329-340 (1976).