A central respiratory stimulant
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Product Categories

Product Type

Small Molecule Modulators
Receptor Pharmacology

Research Area

Doxapram (hydrochloride hydrate)

Item No. 23794

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-2-pyrrolidinone, monohydrochloride, monohydrate
CAS Number
7081-53-0
Synonyms
  • AHR 619
Molecular Formula
C24H30N2O2 • HCl [H2O]
Formula Weight
433.0
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly SolubleMethanol: Slightly SolubleWater: Slightly Soluble
SMILES
O=C(C1(C2=CC=CC=C2)C3=CC=CC=C3)N(CC)CC1CCN4CCOCC4.Cl.O
InChi Code
InChI=1S/C24H30N2O2.ClH.H2O/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21;;/h3-12,22H,2,13-19H2,1H3;1H;1H2
InChi Key
ZOMBFZRWMLIDPX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $63

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    25 mg

    $120

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    Product Description

    Doxapram is a central respiratory stimulant.1 It increases respiration and phrenic nerve activity in anesthetized cats at a dose of 1.0 mg/kg. Doxapram acts through carotid chemoreceptors, lacking activity in anesthetized cats following carotid denervation. Formulations containing doxapram have been used to increase respiration in patients with chronic pulmonary disease, respiratory depression induced by drug overdose, and to stimulate deep breathing post-anesthesia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mitchell, R.A., and Herbert, D.A. Potencies of doxapram and hypoxia in stimulating carotid-body chemoreceptors and ventilation in anesthetized cats. Anesthesiology 42(5), 559-566 (1975).