A synthetic glucocorticoid
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Cortisone Acetate

Item No. 23798

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
21-(acetyloxy)-17-hydroxy-pregn-4-ene-3,11,20-trione
CAS Number
50-04-4
Synonyms
  • Cortisone 21-acetate
  • NSC 49420
Molecular Formula
C23H30O6
Formula Weight
402.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 20 mg/mlEthanol: 2 mg/ml
λmax
238 nm
SMILES
[H][C@]12[C@@]([C@@](CC[C@]3(O)C(COC(C)=O)=O)([H])[C@]3(C)CC2=O)([H])CCC4=CC(CC[C@@]41C)=O
InChi Code
InChI=1S/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-17,20,28H,4-9,11-12H2,1-3H3/t16-,17-,20+,21-,22-,23-/m0/s1
InChi Key
ITRJWOMZKQRYTA-RFZYENFJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

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    50 g

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    Product Description

    Cortisone acetate is a synthetic glucocorticoid with anti-inflammatory properties.1 It decreases the size of Bacillus Calmette-Guérin (BCG) vaccine-induced dermal lesions and tuberculin reactions in rabbits when administered at 2 mg/kg on alternate days over the course of 46 days. It also reduces the number and percentage of activated lesion-infiltrating mononuclear cells and decreases the amount of caseous necrosis and ulceration. Cortisone acetate (2.5 mg/kg per day, s.c.) slows tissue regeneration in a rabbit model of wound healing.2 It also decreases the number of dexamethasone binding sites on isolated human lymphocytes by 30%.3 Formulations containing cortisone acetate have been used to relieve inflammation, pruritic manifestations of corticosteroid-responsive dermatoses, and in the treatment of immune and allergic disorders.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McCue, R.E., Dannenberg, A.M., Jr., Huguchi, S., et al. The effect of cortisone on the accumulation, activation, and necrosis of macrophages in tuberculous lesions. Inflammation 3(2), 159-176 (1978).

    2. Joseph, J., and Tydd, M. The effects of cortisone acetate on tissue regeneration in the rabbit’s ear. J. Anat. 115(Pt. 3), 445-460 (1973).

    3. Schlechte, J.A., Ginsberg, B.H., and Sherman, B.M. Regulation of the glucocorticoid receptor in human lymphocytes. J. Steroid Biochem. 16(1), 69-74 (1982).