An azole antifungal
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Sulconazole (nitrate)

Item No. 23800

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[2-[[(4-chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, mononitrate
CAS Number
61318-91-0
Synonyms
  • RS 44872
Molecular Formula
C18H15Cl3N2S • HNO3
Formula Weight
460.8
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.33 mg/mlEthanol: 0.1 mg/ml
λmax
219 nm
SMILES
ClC1=CC(Cl)=CC=C1C(CN2C=NC=C2)SCC3=CC=C(Cl)C=C3.O=[N](O)=O
InChi Code
InChI=1S/C18H15Cl3N2S.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)
InChi Key
CRKGMGQUHDNAPB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    25 mg

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    Cayman Chemical
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    Product Description

    Sulconazole is an azole antifungal that is active against dermatophyte fungal species, including isolates of various Candida species.1 It acts as a non-specific inhibitor of styrene metabolism by cytochrome P450 (CYP450) enzymes, with Ki values ranging from 0.008 to 3.5 µM against various CYP450 isoforms in human lymphoblast microsomes in vitro.2,3 In rat spleen microsomes, it inhibits the activity of heme oxygenase 1 with an IC50 value of 1.1 µM.4 Sulconazole inhibits DNA damage induced by the metabolism of styrene by bacterial CYP450cam with a Ki value of 204.2 μM in an electrochemical biosensor model.2 Formulations containing sulconazole have been used for the treatment of fungal infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Odds, F.C., Webster, C.E., and Abbot, A.B. Antifungal relative inhibition factors: BAY 1–9139, bifonazole, butoconazole, isoconazole, itraconazole (R 51211), oxiconazole, Ro 14–4767/002, sulconazole, terconazole and vibunazole (BAY n-7133) compared in vitro with nine established antifungal agents. J. Antimicrob. Chemother. 14(2), 105-114 (1984).

    2. Hull, D.O., Bajrami, B., Jansson, I., et al. Characterizing metabolic inhibition using electrochemical enzyme/DNA biosensors. Anal. Chem. 81(2), 716-724 (2009).

    3. Zhang, W., Ramamoorthy, Y., Kilicarslan, T., et al. Inhibition of cytochromes P450 by antifungal imidazole derivatives. Drug Metab. Dispos. 30(3), 314-318 (2002).

    4. Kinobe, R.T., Dercho, R.A., Vlahakis, J.Z., et al. Inhibition of the enzymatic activity of heme oxygenases by azole-based antifungal drugs. J. Pharmacol. Exp. Ther. 319(1), 277-284 (2006).