A prodrug of benazeprilat
Related Products
Active Metabolite(s)
21796Benazeprilat
Labeled Version(s)
30978Benazepril-d5 (hydrochloride)
Metabolite(s)
27619Benazepril Acyl-β-D-Glucuronide
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Benazepril (hydrochloride)

Item No. 23804

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3S)-3-[[1S-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid, monohydrochloride
CAS Number
86541-74-4
Synonyms
  • CGS 14824A
Molecular Formula
C24H28N2O5 • HCl
Formula Weight
461.0
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 20 mg/mlEthanol: 1 mg/ml
λmax
204, 237 nm
SMILES
O=C(OCC)[C@H](CCC1=CC=CC=C1)N[C@H]2CCC3=C(C=CC=C3)N(CC(O)=O)C2=O.Cl
InChi Code
InChI=1S/C24H28N2O5.ClH/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);1H/t19-,20-;/m0./s1
InChi Key
VPSRQEHTHIMDQM-FKLPMGAJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 mg

    $63

    Add

    100 mg

    $118

    Add

    500 mg

    $543

    Add

    1 g

    $962

    Add
    Product Description

    Benazepril is a prodrug of the angiotensin converting enzyme (ACE) inhibitor benazeprilat (Item No. 21796).1 It is metabolized to benazeprilat by hepatic esterases. Benazepril inhibits the in vitro enzymatic activity of partially purified ACE isolated from rabbit lung (IC50 = 2 nM).2 It decreases the triglyceride and total cholesterol levels in normotensive rats when administered at a dose of 30 mg/kg and decreases aortic atherosclerosis in cholesterol-fed rabbits when administered at a dose of 3 mg/kg per day.3 Benazepril (0.1-10 mg/kg per day) reduces blood pressure in spontaneously hypertensive rats.4 It also decreases proteinuria in cats with chronic kidney disease when administered at doses ranging from 0.5 to 1 mg/kg per day.5 Formulations containing benazepril have been used to treat hypertension, congestive heart failure, and chronic kidney disease in both human and veterinary medicine.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Toutain, P.L., and Lefèbvre, H.P. Pharmacokinetics and pharmacokinetic/pharmacodynamic relationships for angiotensin-converting enzyme inhibitors. J. Vet. Pharmacol. Ther. 27(6), 515-525 (2004).

    2. Ksander, G.M., Erion, M., Yuan, A.M., et al. Dual angiotensin converting enzyme/thromboxane synthase inhibitors. J. Med. Chem. 37(12), 1823-1832 (1994).

    3. Yamamoto, S., Takemori, E., Hasegawa, Y., et al. General pharmacology of the novel angiotensin converting enzyme inhibitor benazepril hydrochloride. Effects on cardiovascular, visceral and renal functions and on hemodynamics. Arzneimittelforschung 41(9), 913-923 (1991).

    4. Watthey, J.W.H., Stanton, J.L., Desai, M., et al. Synthesis and biological properties of (carboxyalkyl)amino-substituted bicyclic lactam inhibitors of angiotensin converting enzyme. J. Med. Chem. 28(10), 1511-1516 (1985).

    5. King, J.N., Gunn-Moore, D.A., Tasker, S., et al. Tolerability and efficacy of benazepril in cats with chronic kidney disease. J. Vet. Intern. Med. 20(5), 1054-1064 (2006).