A piperazine salt form of estrone 3-sulfate
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Alternative(s)
36989Estrone 3-sulfate (sodium salt)
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Estropipate

Item No. 23806

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(sulfooxy)-estra-1,3,5(10)-trien-17-one, compd. with piperazine
CAS Number
7280-37-7
Synonyms
  • Piperazine Estrone Sulfate
Molecular Formula
C18H22O5S • C4H10N2
Formula Weight
436.6
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly SolubleMethanol: Slightly Soluble
SMILES
O=C1CC[C@@]2([H])[C@]3([H])CCC4=CC(OS(O)(=O)=O)=CC=C4[C@@]3([H])CC[C@@]21C.C5CNCCN5
InChi Code
InChI=1S/C18H22O5S.C4H10N2/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;1-2-6-4-3-5-1/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);5-6H,1-4H2/t14-,15-,16+,18+;/m1./s1
InChi Key
HZEQBCVBILBTEP-ZFINNJDLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Product Description

    Estropipate is a piperazine salt form of estrone 3-sulfate (Item No. 36989), which is an endogenous steroid that is converted into estrone (Item No. 10006485) in vivo.1 Estropipate is also an inhibitor of organic anion transport polypeptide 1B1 (OATP1B1) that is selective for OATP1B1 over OATP1B3 (IC50s = 0.06 and 19.3 µM, respectively).2 Formulations containing estropipate have been used in the treatment of menopausal symptoms and for the prevention of osteoporosis in high risk populations.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Banerjee, N., Fonge, H., Mikahil, A., et al. Estrone-3-sulphate, a potential novel ligand for targeting breast cancers. PLoS One 8(5), e64069 (2013).

    2. Gui, C., Obaidat, A., Chaguturu, R., et al. Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3. Curr. Chem. Genomics 4, (2010).