A corticosteroid
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Diflorasone Diacetate

Item No. 23808

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
17,21-bis(acetyloxy)-6α,9-difluoro-11β-hydroxy-16β-methyl-pregna-1,4-diene-3,20-dione
CAS Number
33564-31-7
Synonyms
  • U-34865
Molecular Formula
C26H32F2O7
Formula Weight
494.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly SolubleMethanol: Slightly Soluble
SMILES
F[C@]12[C@@]([C@@](C[C@H](C)[C@]3(OC(C)=O)C(COC(C)=O)=O)([H])[C@]3(C)C[C@@H]2O)([H])C[C@H](F)C4=CC(C=C[C@@]41C)=O
InChi Code
InChI=1S/C26H32F2O7/c1-13-8-17-18-10-20(27)19-9-16(31)6-7-23(19,4)25(18,28)21(32)11-24(17,5)26(13,35-15(3)30)22(33)12-34-14(2)29/h6-7,9,13,17-18,20-21,32H,8,10-12H2,1-5H3/t13-,17-,18-,20-,21-,23-,24-,25-,26-/m0/s1
InChi Key
BOBLHFUVNSFZPJ-JOYXJVLSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Diflorasone is a corticosteroid with anti-inflammatory activity.1 It reduces production of the inflammatory cytokines Il-6, Il-4, and macrophage inflammatory protein-2 (Mip-2) and completely inhibits swelling in the ears of toluene-2,4-diisocyaniate-sensitized mice following topical administration of 20 µL of a 0.05% solution. Diflorasone inhibits RANTES and thymus and activation regulated chemokine (TARC) in a dinitrochlorobenzene-induced mouse model of allergic contact dermatitis.2 It also inhibits proliferation of human keratinocytes in vitro and reduces epidermal thickening in a mouse model of psoriasis induced by imiquimod (Item No. 14956).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bäumer, W., Gorr, G., Hoppmann, J., et al. AWD 12-281, a highly selective phosphodiesterase 4 inhibitor, is effective in the prevention and treatment of inflammatory reactions in a model of allergic dermatitis. J. Pharm. Pharmacol. 55(8), 1107-1114 (2003).

    2. Bäumer, W., Seegers, U., Braun, M., et al. TARC and RANTES, but not CTACK, are induced in two models of allergic contact dermatitis. Effects of cilomilast and diflorasone diacetate on T-cell-attracting chemokines. Br. J. Dermatol. 151(4), 823-830 (2004).

    3. Schaper, K., Dickhaut, J., Japtok, L., et al. Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis. J. Dermatol. Sci. 71(1), 29-36 (2013).