An anthelmintic
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Ivermectin B1b

Item No. 23824

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-avermectin A1a
CAS Number
70209-81-3
Synonyms
  • 22,23-dihydro Avermectin B1b
Molecular Formula
C47H72O14
Formula Weight
861.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: SolubleDMSO: SolubleEthanol: SolubleMethanol: Soluble
SMILES
C/C([C@@H](O[C@@]1([H])C[C@H](OC)[C@@H](O[C@]2([H])O[C@@H](C)[C@H](O)[C@@H](OC)C2)[C@H](C)O1)[C@@H](C)/C=C/C=C(CO3)/[C@@]([C@@]3([H])[C@H](O)C(C)=C4)(O)[C@]4([H])C5=O)=C\C[C@]6([H])C[C@@](O5)([H])C[C@]7(CC[C@H](C)[C@](C(C)C)([H])O7)O6
InChi Code
InChI=1S/C47H72O14/c1-24(2)41-27(5)16-17-46(61-41)22-33-19-32(60-46)15-14-26(4)42(25(3)12-11-13-31-23-54-44-39(48)28(6)18-34(45(50)57-33)47(31,44)51)58-38-21-36(53-10)43(30(8)56-38)59-37-20-35(52-9)40(49)29(7)55-37/h11-14,18,24-25,27,29-30,32-44,48-49,51H,15-17,19-23H2,1-10H3/b12-11+,26-14+,31-13+/t25-,27-,29-,30-,32+,33-,34-,35-,36-,37-,38-,39+,40-,41+,42-,43-,44+,46+,47+/m0/s1
InChi Key
VARHUCVRRNANBD-PVVXTEPVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Ivermectin B1b is the minor component (<20%) of the anthelmintic ivermectin, which is mainly comprised of ivermectin B1a (>80%; Item No. 18768).1 It produces antiparasitic activity by binding to glutamate-gated chloride channels expressed on nematode neurons and pharyngeal muscle cells, inducing irreversible channel opening and very long-lasting hyperpolarization/depolarization of the neuron/muscle cell, thereby blocking further function.2,3 Formulations containing ivermectin inhibit replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero/hSLAM cells.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Campbell, W.C., Fisher, M.H., Stapley, E.O., et al. Ivermectin: A potent new antiparasitic agent. Science 221(4613), 823-828 (1983).

    2. Wolsetnholme, A.J., and Rogers, A.T. Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. Parasitology 131(Suppl), S85-S95 (2005).

    3. Arena, J.P., Liu, K.K., Paress, P.S., et al. The mechanism of action of avermectins in Caenorhabditis elegans: Correlation between activation of glutamate-sensitive chloride current, membrane binding, and biological activity. J. Parasitol. 81(2), 286-294 (1995).

    4. Caly, L., Druce, J.D., Catton, M.G., et al. The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro. Antiviral Res. 178:104787, (2020).