A fluorinated corticosteroid receptor agonist
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Flunisolide

Item No. 23842

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6α-fluoro-11β,21-dihydroxy-16α,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione
CAS Number
3385-03-3
Synonyms
  • RS 3999
Molecular Formula
C24H31FO6
Formula Weight
434.5
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:2): 0.2 mg/ml
λmax
238 nm
SMILES
O=C1C=C[C@@]2(C)C([C@@H](F)C[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@]5([H])[C@@]4(C(CO)=O)OC(C)(C)O5)=C1
InChi Code
InChI=1S/C24H31FO6/c1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26/h5-7,13-14,16-17,19-20,26,28H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,20+,22-,23-,24+/m0/s1
InChi Key
XSFJVAJPIHIPKU-XWCQMRHXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $75

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    100 mg

    $128

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    Product Description

    Flunisolide is a fluorinated corticosteroid receptor agonist that induces reversible pyloric hyalinization in CD-1 mice following oral administration at a dose of 200 μg/kg per day.1 Formulations containing flunisolide have been used for the treatment of asthma.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McKevitt, T.P., Giffen, P., Woodfine, J.A., et al. Hyalinization of the pyloric stomach in CD-1 mice following oral (dietary) administration of the corticosteroid agonists mometasone furoate, budesonide, and flunisolide. Toxicol. Pathol. 39(6), 958-968 (2011).

    2. O'Callaghan, C., White, J.A., and Kantar, A. Nebulization of corticosteroids to asthmatic children: Large variation in dose inhaled. Respirology 19(2), 276-279 (2014).