An arylurea fatty acid
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CAY10726

Item No. 23859

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
16-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-hexadecanoic acid
CAS Number
1611446-66-2
Molecular Formula
C24H36ClF3N2O3
Formula Weight
493.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS(pH7.2) (1:2): 0.33 mg/mlDMSO: 5 mg/mlEthanol: 12 mg/ml
λmax
253 nm
SMILES
ClC1=CC=C(NC(NCCCCCCCCCCCCCCCC(O)=O)=O)C=C1C(F)(F)F
InChi Code
InChI=1S/C24H36ClF3N2O3/c25-21-16-15-19(18-20(21)24(26,27)28)30-23(33)29-17-13-11-9-7-5-3-1-2-4-6-8-10-12-14-22(31)32/h15-16,18H,1-14,17H2,(H,31,32)(H2,29,30,33)
InChi Key
SSBRGGKJZDBNKL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $153

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    10 mg

    $268

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    25 mg

    $587

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    Product Description

    CAY10726 is an arylurea fatty acid.1 It decreases ATP production by 28% in MDA-MB-231 breast cancer cells when used at a concentration of 10 μM. CAY10726 decreases proliferation and initiates apoptosis in MDA-MB-231 cells via depletion of the phospholipid cardiolipin and its precursor phosphatidylglycerol from the mitochondrial membrane. In vivo, CAY10726 (2.5-40 mg/kg) reduces tumor volume and increases tumor cell apoptosis in a mouse MDA-MB-231 breast cancer xenograft model in a dose-dependent manner.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rawling, T., Choucair, H., Koolaji, N., et al. A novel arylurea fatty acid that targets the mitochondrion and depletes cardiolipin to promote killing of breast cancer cells. J. Med. Chem. 60(20), 8661-8666 (2017).