A dopamine receptor agonist
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(±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (hydrobromide)

Item No. 23866

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-amino-5,6,7,8-tetrahydro-2,3-naphthalenediol, monohydrobromide
CAS Number
13575-86-5
Synonyms
  • (±)-ADTN
  • 6,7-ADTN
  • 6,7-diOHATN
  • NSC 287353
Molecular Formula
C10H13NO2 • HBr
Formula Weight
260.1
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Water: 100 mM
SMILES
NC1CCC2=CC(O)=C(O)C=C2C1.Br
InChi Code
InChI=1S/C10H13NO2.BrH/c11-8-2-1-6-4-9(12)10(13)5-7(6)3-8;/h4-5,8,12-13H,1-3,11H2;1H
InChi Key
ZGHHIOBQEXZBAG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    50 mg

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    Product Description

    (±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (6,7-ADTN) is a dopamine receptor agonist (EC50s = 3.5 and 0.65 μM in rat striatal and nucleus accumbens homogenates, respectively).1 6,7-ADTN stimulates production of cAMP in rat striatal homogenates, a process that is reduced by 70% in the presence of the dopamine antagonist fluphenazine (Item No. 23555) at a concentration of 1 μM. In vivo, 6,7-ADTN induces hyperlocomotion in rats when injected bilaterally at a dose of 100 nmol per side into the nucleus accumbens. It increases cAMP production and glycoprotein secretion in the albumen gland of H. duryi (snail).2 It also reduces sucrose feeding in R. maderae (cockroach) nymphs.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Woodruff, G.N., Watling, K.J., Andrews, C.D., et al. Dopamine receptors in rat striatum and nucleus accumbens; conformational studies using rigid analogues of dopamine. J. Pharm. Pharmacol. 29(7), 422-427 (1977).

    2. Mukai, S.T., Kiehn, L., and Saleuddin, A.S.M. Dopamine stimulates snail albumen gland glycoprotein secretion through the activation of a D1-like receptor. J. Exp. Biol. 207(Pt 14), 2507-2518 (2004).

    3. Allen, J.M., Van Kummer, B.H., and Cohen, R.W. Dopamine as an anorectic neuromodulator in the cockroach Rhyparobia maderae. J. Exp. Biol. 214(Pt 22), 3843-3849 (2011).