An inhibitor of HDAC3, HDAC6, and HDAC8
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Droxinostat

Item No. 23869

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(4-chloro-2-methylphenoxy)-N-hydroxy-butanamide
CAS Number
99873-43-5
Synonyms
  • NS 41080
Molecular Formula
C11H14ClNO3
Formula Weight
243.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH7.2)(1:20): 0.05 mg/ml
λmax
231, 281 nm
SMILES
ClC1=CC(C)=C(OCCCC(NO)=O)C=C1
InChi Code
InChI=1S/C11H14ClNO3/c1-8-7-9(12)4-5-10(8)16-6-2-3-11(14)13-15/h4-5,7,15H,2-3,6H2,1H3,(H,13,14)
InChi Key
JHSXDAWGLCZYSM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $37

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    5 mg

    $90

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    10 mg

    $158

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    25 mg

    $349

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    Cayman Chemical
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    Product Description

    Droxinostat is an inhibitor of histone deacetylase (HDAC) 3, 6, and 8 (IC50s = 16.9, 2.47, and 1.46 μM, respectively).1 It is selective for HDAC3, 6, and 8 over HDAC1, 2, 7, 9, and 10 (IC50s = >20 μM). Droxinostat increases histone H3 and H4 acetylation in PPC-1 prostate, OVCAR3 ovarian, U937 leukemia, HT-29 colon, and T47D breast cancer cells. It also inhibits proliferation and colony formation of SMMC-7721 and HepG2 hepatocellular carcinoma cell lines via activation of mitochondrial apoptosis and reduction of cellular FLICE-inhibitory protein (c-FLIP).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wood, T.E., Dalili, S., Simpson, C.D., et al. Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. Mol. Cancer Ther. 9(1), 246-256 (2010).

    2. Liu, J., Li, G., Wang, X., et al. Droxinostat, a histone deacetylase inhibitor, induces apoptosis in hepatocellular carcinoma cell lines via activation of the mitochondrial pathway and downregulation of FLIP. Transl. Oncol. 9(1), 70-78 (2016).