An antagonist of σ1 receptors
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

BD 1063 (hydrochloride)

Item No. 23874

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[2-(3,4-dichlorophenyl)ethyl]-4-methyl-piperazine, dihydrochloride
CAS Number
206996-13-6
Molecular Formula
C13H18Cl2N2 • 2HCl
Formula Weight
346.1
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 11 mg/mlDMSO: 16 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
ClC1=C(Cl)C=CC(CCN2CCN(C)CC2)=C1.Cl.Cl
InChi Code
InChI=1S/C13H18Cl2N2.2ClH/c1-16-6-8-17(9-7-16)5-4-11-2-3-12(14)13(15)10-11;;/h2-3,10H,4-9H2,1H3;2*1H
InChi Key
NXFDBTLQOARIMH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $69

    Add

    10 mg

    $120

    Add
    Product Description

    BD 1063 is an antagonist of sigma-1 (σ1) receptors (Ki = 9 nM).1 It is selective for σ1 receptors over σ2 (Ki = 449 nM) and serotonin 5-HT2 receptors (Ki = 2,552 nM), as well as opioid, dopamine D2, PCP, serotonin 5-HT1, α1-, α2-, and β-adrenergic receptors where it has Ki values of greater than 10 µM. BD 1063 (30 mg/kg) inhibits locomotor activity induced by cocaine (Item Nos. 16186 | ISO60176) in mice and decreases ethanol intake in a dose-dependent manner in two rat models of excessive drinking when administered at doses ranging from 3.3 to 11 mg/kg.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McCracken, K.A., Bowen, W.D., de Costa, B.R., et al. Two novel σ receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity. Eur. J. Pharmacol. 370(3), 225-232 (1999).

    2. Sabino, V., Cottone, P., Zhao, Y., et al. The sigma receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking. Neurophychopharmacology 34(6), 1482-1493 (2009).