An antagonist of σ1 receptors
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BD 1063 (hydrochloride)

Item No. 23874

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[2-(3,4-dichlorophenyl)ethyl]-4-methyl-piperazine, dihydrochloride
CAS Number
206996-13-6
Molecular Formula
C13H18Cl2N2 • 2HCl
Formula Weight
346.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 11 mg/mlDMSO: 16 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
ClC1=C(Cl)C=CC(CCN2CCN(C)CC2)=C1.Cl.Cl
InChi Code
InChI=1S/C13H18Cl2N2.2ClH/c1-16-6-8-17(9-7-16)5-4-11-2-3-12(14)13(15)10-11;;/h2-3,10H,4-9H2,1H3;2*1H
InChi Key
NXFDBTLQOARIMH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

    $120

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    Product Description

    BD 1063 is an antagonist of sigma-1 (σ1) receptors (Ki = 9 nM).1 It is selective for σ1 receptors over σ2 (Ki = 449 nM) and serotonin 5-HT2 receptors (Ki = 2,552 nM), as well as opioid, dopamine D2, PCP, serotonin 5-HT1, α1-, α2-, and β-adrenergic receptors where it has Ki values of greater than 10 µM. BD 1063 (30 mg/kg) inhibits locomotor activity induced by cocaine (Item Nos. 16186 | ISO60176) in mice and decreases ethanol intake in a dose-dependent manner in two rat models of excessive drinking when administered at doses ranging from 3.3 to 11 mg/kg.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McCracken, K.A., Bowen, W.D., de Costa, B.R., et al. Two novel σ receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity. Eur. J. Pharmacol. 370(3), 225-232 (1999).

    2. Sabino, V., Cottone, P., Zhao, Y., et al. The sigma receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking. Neurophychopharmacology 34(6), 1482-1493 (2009).