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(+)-CP 101,606

Item № 23884
CAS № 134234-12-1
Purity ≥98%
product image
                (CAS 134234-12-1)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $58.00 0.00
     10 mg $75.00 0.00
     25 mg $174.00 0.00

Pricing updated 2019-07-18. Prices are subject to change without notice.

Description
Synonyms
  • CP 98,113

CP 101,606 is a noncompetitive antagonist of NDMA receptors containing the NR2B subunit (Kd = 4.2 nM).1 CP 101,606 is highly selective for NR1/NR2B-containing NMDA receptors over NR1, NR2A, and NR2B subunits alone and NR1/NR2A receptors in HEK293 cell homogenates. In vivo, CP 101,606 (30 mg/kg, s.c.) inhibits mechanical hyperalgesia following carrageenan challenge in rats.2 It also inhibits licking behavior in rats induced by capsaicin (Item No. 92350) and phorbol-12-myristate-13-acetate (PMA; Item No. 10008014; ED50s = 7.5 and 5.7 mg/kg, respectively). CP 101,606 reverses catalepsy in rats induced by haloperidol (Item No. 12014) with an ED50 value of 0.4 mg/kg.3 CP 101,606 (1 mg/kg, s.c.) alone or in combination with L-DOPA methyl ester (Item No. 16149) temporarily improves parkinsonian symptoms in an MPTP model of Parkinson's disease in rhesus monkeys.

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Technical Information
Formal Name
4-hydroxy-αS-(4-hydroxyphenyl)-βS-methyl-4-phenyl-1-piperidineethanol
CAS Number
134234-12-1
Synonyms
  • CP 98,113
Molecular Formula
C20H25NO3
Formula Weight
327.4
Purity
≥98%
Formulation
A crystalline solid
λmax
227, 279 nm
SMILES
OC1=CC=C([C@H](O)[C@H](C)N2CCC(C3=CC=CC=C3)(O)CC2)C=C1
InChI Code
InChI=1S/C20H25NO3/c1-15(19(23)16-7-9-18(22)10-8-16)21-13-11-20(24,12-14-21)17-5-3-2-4-6-17/h2-10,15,19,22-24H,11-14H2,1H3/t15-,19+/m0/s1
InChI Key
QEMSVZNTSXPFJA-HNAYVOBHSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

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References & Product Citations
Product Description References

1. Chazot, P.L., Lawrence, S., and Thompson, C.L. Studies on the subtype selectivity of CP-101,606: Evidence for two classes of NR2B-selective NMDA receptor antagonists Neuropharmacology 42(3), 319-324 (2002).

2. Taniguchi, K., Shinjo, K., Mizutani, M., et al. Antinociceptive activity of CP-101,606, an NMDA receptor NR2B subunit antagonist Br. J. Pharmacol. 122(5), 809-812 (1997).

3. Steece-Collier, K., Chambers, L.K., Jaw-Tsai, S.S., et al. Antiparkinsonian actions of CP-101,606, an antagonist of NR2B subunit-containing N-methyl-d-aspartate receptors Exp. Neurol. 163(1), 239-243 (2000).

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