A partial agonist of central benzodiazepine receptors
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Pipequaline

Item No. 23888

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-phenyl-4-[2-(4-piperidinyl)ethyl]-quinoline
CAS Number
77472-98-1
Synonyms
  • 45319 RP
  • PK 8165
Molecular Formula
C22H24N2
Formula Weight
316.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml
λmax
257 nm
SMILES
C12=CC=CC=C1N=C(C3=CC=CC=C3)C=C2CCC4CCNCC4
InChi Code
InChI=1S/C22H24N2/c1-2-6-18(7-3-1)22-16-19(11-10-17-12-14-23-15-13-17)20-8-4-5-9-21(20)24-22/h1-9,16-17,23H,10-15H2
InChi Key
AMEWZCMTSIONOX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $90

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    50 mg

    $392

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    100 mg

    $653

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    Product Description

    Pipequaline is a partial agonist of central benzodiazepine receptors (Ki = 78 nM in a radioligand binding assay).1 In mice, pipequaline enhances the effects of diazepam (Item No. ISO60177), further reducing foot shock-induced fighting behavior and the number of maximal electroshock-induced seizures and potentiating the muscle relaxant and hypnotic effects.2 Pipequaline also increases drinking in the Vogel punished drinking task indicating anxiolytic-like activity that can be reversed by the benzodiazepine receptor antagonist flumazenil (Item No. 14252).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Le Fur, G., Mizoule, J., Burgevin, M.C., et al. Multiple benzodiazepine receptors: Evidence of a dissociation between anticonflict and anticonvulsant properties by PK 8165 and PK 9084 (two quinoline derivatives). Life Sci. 28(13), 1439-1448 (1981).

    2. Mizoule, J., Rataud, J., Uzan, A., et al. Pharmacological evidence that PK 8165 behaves as a partial agonist of brain type benzodiazepine receptors. Arch. Int. Pharmacodyn. Ther. 271(2), 189-197 (1984).