A prodrug of phenytoin
Related Products
Active Metabolite(s)
24037Phenytoin
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Fosphenytoin (sodium salt)

Item No. 23889

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,5-diphenyl-3-[(phosphonooxy)methyl]-2,4-imidazolidinedione, disodium salt
CAS Number
92134-98-0
Synonyms
  • ACC-9653
  • Cl-982
Molecular Formula
C16H13N2O6P • 2Na
Formula Weight
406.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: >1mg/mlEthanol: >1mg/ml
SMILES
O=C(C(C1=CC=CC=C1)(C2=CC=CC=C2)N3)N(COP([O-])([O-])=O)C3=O.[Na+].[Na+]
InChi Code
InChI=1S/C16H15N2O6P.2Na/c19-14-16(12-7-3-1-4-8-12,13-9-5-2-6-10-13)17-15(20)18(14)11-24-25(21,22)23;;/h1-10H,11H2,(H,17,20)(H2,21,22,23);;/q;2*+1/p-2
InChi Key
GQPXYJNXTAFDLT-UHFFFAOYSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 mg

    $49

    Add

    100 mg

    $93

    Add

    250 mg

    $202

    Add

    500 mg

    $354

    Add
    Product Description

    Fosphenytoin is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker, in vivo.1,2,3 It induces less tissue damage compared with two other phenytoin prodrugs in rats following subcutaneous and intramuscular administration.1 Fosphenytoin has anticonvulsant activity in a mouse model of maximal electroshock seizures similar to that of phenytoin (ED50s = 16 and 8 mg/kg, respectively).2 It also has antiarrhythmic activity in isolated guinea pig atria and in anesthetized dogs. Formulations containing fosphenytoin have been used in the treatment of status epilepticus.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Varia, S.A., and Stella, V.J. Phenytoin prodrugs VI: In vivo evaluation of a phosphate ester prodrug of phenytoin after parenteral administration to rats. J. Pharm. Sci. 73(8), 1087-1090 (1984).

    2. Smith, R.D., Brown, B.S., Maher, R.W., et al. Pharmacology of ACC-9653 (phenytoin prodrug). Epilepsia 30(Suppl. 2), S15-S21 (1989).

    3. Boucher, B.A. Fosphenytoin: A novel phenytoin prodrug. Pharmacotherapy 16(5), 777-791 (1996).