An inhibitor of lysosomal acid lipase
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Lalistat 1

Item No. 23891

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-morpholinecarboxylic acid, 4-(1-piperidinyl)-1,2,5-thiadiazol-3-yl ester
CAS Number
501104-16-1
Molecular Formula
C12H18N4O3S
Formula Weight
298.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/mlEthanol:PBS(pH 7.2) (1:5): 0.16 mg/ml
λmax
302 nm
SMILES
O=C(N1CCOCC1)OC2=NSN=C2N3CCCCC3
InChi Code
InChI=1S/C12H18N4O3S/c17-12(16-6-8-18-9-7-16)19-11-10(13-20-14-11)15-4-2-1-3-5-15/h1-9H2
InChi Key
XAWUWPUYJUOUOF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    10 mg

    $236

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    50 mg

    $1,053

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    Product Description

    Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL; IC50 = 68 nM using purified human LAL).1 It is selective for LAL over human pancreatic and bovine milk lipoprotein lipases up to a concentration of 10 µM.2 Lalistat 1 (0.01-10 µM) reduces cholesterol accumulation in lysosome-like storage organelles in GM03123 human fibroblast cells deficient in NPC1, a membrane protein found in late endosomes, in a concentration-dependent manner but has little effect on cholesterol accumulation in NPC1-deficient CHO cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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