An anticonvulsant
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Product Categories

Product Type

Biochemicals

Research Area

Neuroscience
Seizure Disorders

Trimethadione

Item No. 23893

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,5,5-trimethyl-2,4-oxazolidinedione
CAS Number
127-48-0
Synonyms
  • NSC 15799
  • NSC 169503
Molecular Formula
C6H9NO3
Formula Weight
143.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly SolubleMethanol: Slightly Soluble
SMILES
O=C(OC1(C)C)N(C)C1=O
InChi Code
InChI=1S/C6H9NO3/c1-6(2)4(8)7(3)5(9)10-6/h1-3H3
InChi Key
IRYJRGCIQBGHIV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $36

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    100 mg

    $63

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    250 mg

    $135

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    Product Description

    Trimethadione is an anticonvulsant.1,2 It decreases the levels of α-oxoglutarate, malate, and fumarate in the brain as well as plasma glucose levels in rats.1 Trimethadione increases latency to first pentetrazole-induced clonic seizure in mice (ED50 = 10 mg/kg).2 It also inhibits absence-like seizures but not tonic convulsions in spontaneously epileptic rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nahorski, S.R. Biochemical effects of the anticonvulsants trimethadione, ethosuximide and chlordiazepoxide in rat brain. J. Neurochem. 19(8), 1937-1946 (1972).

    2. Frey, H.H. Determination of the anticonvulsant potency of unmetabolized trimethadione. Acta. Pharmacol. Toxicol. (Copenh) 27(4), 295-300 (1969).

    3. Sasa, M., Ohno, Y., Ujihara, H., et al. Effects of antiepileptic drugs on absence-like and tonic seizures in the spontaneously epileptic rat, a double mutant rat. Epilepsia 29(5), 505-513 (1988).