An inhibitor of DAAO
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D-Amino Acid Oxidase Inhibitor

Item No. 23894

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4H-thieno[3,2-b]pyrrole-5-carboxylic acid
CAS Number
39793-31-2
Synonyms
  • DAAO inhibitor
Molecular Formula
C7H5NO2S
Formula Weight
167.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.3 mg/mlEthanol: 2 mg/ml
λmax
222, 286 nm
SMILES
OC(C1=CC(SC=C2)=C2N1)=O
InChi Code
InChI=1S/C7H5NO2S/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10)
InChi Key
PMHDSACGRKBACK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $28

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    100 mg

    $42

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    250 mg

    $97

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    500 mg

    $165

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    Product Description

    D-Amino acid oxidase inhibitor is an inhibitor of D-amino acid oxidase (DAAO) with IC50 values of 145 and 114 nM in CHO cells expressing human and rat DAAO, respectively.1 It is selective for DAAO over a panel of 150 enzymes, receptors, and ion channels when used at a concentration of 30 μM. D-Amino acid oxidase inhibitor (10-200 mg/kg, i.p.) inhibits DAAO activity in rat kidney and cerebellum in a dose- and time-dependent manner. It increases levels of D-serine in rat plasma and cerebral spinal fluid (CSF) but has no effect on hyperlocomotion or dopamine efflux in the nucleus accumbens induced by amphetamine (Item No. ISO60188) in rats. DAAO inhibitor reduces formalin-induced paw flinching in rats (EC50 = 0.17 μg per animal) indicating an antinociceptive effect.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Smith, S.M., Uslaner, J.M., Yao, L., et al. The behavioral and neurochemical effects of a novel D-amino acid oxidase inhibitor compound 8 [4H-thieno [3,2-b]pyrrole-5-carboxylic acid] and D-serine. J. Pharmacol. Exp. Ther. 328(3), 921-930 (2009).

    2. Gong, N., Gao, Z.-Y., Wang, Y.-C., et al. A series of D-amino acid oxidase inhibitors specifically prevents and reverses formalin-induced tonic pain in rats. J. Pharmacol. Exp. Ther. 336(1), 282-293 (2011).