An inhibitor of PDE3
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Amrinone

Item No. 23898

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-amino-[3,4'-bipyridin]-6(1H)-one
CAS Number
60719-84-8
Synonyms
  • WIN 40,680
Molecular Formula
C10H9N3O
Formula Weight
187.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.3 mg/mlDMSO: 0.5 mg/ml
λmax
202, 246, 326 nm
SMILES
NC1=CC(C2=CC=NC=C2)=CNC1=O
InChi Code
InChI=1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)
InChi Key
RNLQIBCLLYYYFJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $49

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    500 mg

    $93

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    1 g

    $160

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    5 g

    $748

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    Product Description

    Amrinone is an inhibitor of phosphodiesterase 3 (PDE3; IC50 = 19.5 µM).1 It increases developed tension and contractile force in isolated cat papillary muscle.2 Amrinone (1-10 mg/kg) has positive inotropic effects, increasing the rate and force of heart contraction in anesthetized and unanesthetized dogs.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kariya, T., Wille, L.J., and Dage, R.C. Biochemical studies on the mechanism of cardiotonic activity of MDL 17,043. J. Cardiovasc. Pharmacol. 4(3), 509-514 (1982).

    2. Alousi, A.A., Farah, A.E., Lesher, G.Y., et al. Cardiotonic activity of amrinone--Win 40680 [5-amino-3,4'-bipyridine-6(1H)-one]. Circ. Res. 45(5), 666-677 (1979).