A modulator of sickle hemoglobin
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Product Categories

Product Type

Biochemicals

Research Area

Cardiovascular System
Blood
Erythrocytes & Hemoglobin

GBT-440

Item No. 23933

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-hydroxy-6-[[2-[1-(1-methylethyl)-1H-pyrazol-5-yl]-3-pyridinyl]methoxy]-benzaldehyde
CAS Number
1446321-46-5
Synonyms
  • Voxelotor
Molecular Formula
C19H19N3O3
Formula Weight
337.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMSO: 33 mg/mlDMSO:PBS (pH 7.2) (1:5): 0.16 mg/mlEthanol: 20 mg/ml
λmax
272, 276 nm
SMILES
OC1=C(C=O)C(OCC2=CC=CN=C2C3=CC=NN3C(C)C)=CC=C1
InChi Code
InChI=1S/C19H19N3O3/c1-13(2)22-16(8-10-21-22)19-14(5-4-9-20-19)12-25-18-7-3-6-17(24)15(18)11-23/h3-11,13,24H,12H2,1-2H3
InChi Key
FWCVZAQENIZVMY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $83

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    10 mg

    $138

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    25 mg

    $241

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    Product Description

    GBT-440 is a modulator of sickle hemoglobin (HbS) that binds covalently to the N-terminal valine of the α chain of HbS.1 In vitro, GBT-440 increases HbS affinity for oxygen (EC50s = 8.2 and 415 μM for purified HbS and whole blood from sickle cell anemia patients, respectively) and delays oxygen release from and polymerization of HbS in a concentration-dependent manner. GBT-440 (100-150 mg/kg) increases red blood cell half-life and reduces sickling ex vivo in whole blood isolated from a murine model of sickle cell anemia. It also reduces ex vivo sickling of sickle cell trait red blood cells under conditions of hypoxia, acidosis, and dehydration.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Oksenberg, D., Dufu, K., Patel, M.P., et al. GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease. Br. J. Haematol. 175(1), 141-153 (2016).

    2. Dufu, K., Lehrer-Graiwer, J., Ramos, E., et al. GBT440 inhibits sickling of sickle cell trait blood under in vitro conditions mimicking strenuous exercise. Hematol. Rep. 8(3), 6637 (2016).