An ectoparasiticide and antipruritic
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Crotamiton

Item No. 23943

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-ethyl-N-(2-methylphenyl)-2-butenamide
CAS Number
483-63-6
Synonyms
  • N-Ethyl-o-Crotonotoluidide
Molecular Formula
C13H17NO
Formula Weight
203.3
Purity
≥95%
Formulation (Request formulation change)
A neat oil
Solubility(Learn about Variance in Solubility)
DMF: 100 mg/mlDMSO: 100 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 50 mg/ml
λmax
205, 208 nm
SMILES
CC1=C(N(CC)C(/C=C/C)=O)C=CC=C1
InChi Code
InChI=1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3/b8-4+
InChi Key
DNTGGZPQPQTDQF-XBXARRHUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $225

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    5 g

    $506

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    10 g

    $788

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    25 g

    $1,406

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    Cayman Chemical
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    Product Description

    Crotamiton is an ectoparasiticide and antipruritic agent.1,2,3 It blocks the mouse transient receptor potential vanilloid 4 (TRPV4) channel expressed in HEK293 cells in a calcium-dependent manner (IC50s = 223.5 and 15.5 μM in buffer containing 0 and 2 mM calcium, respectively).2 It inhibits scratching behavior in mice induced by the TRPV4 agonist GSK1016790A (Item No. 17289). Topical application of crotamiton (0.025 g of a 10% ointment) also inhibits scratching behavior in mice induced by histamine, serotonin (Item No. 14332), and the proteinase-activated receptor 2 (PAR2) agonist SLIGRL-NH2 (Item No. 16723).3 Formulations containing crotamiton have been used to eradicate scabies and in the treatment of symptomatic pruritic skin.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Goldust, M., Rezaee, E., and Raghiafar, R. Topical ivermectin versus crotamiton cream 10% for the treatment of scabies. Int. J. Dermatol. 53(7), 904-908 (2014).

    2. Kittaka, H., Yamanoi, Y., and Tominaga, M. Transient receptor potential vanilloid 4 (TRPV4) channel as a target of crotamiton and its bimodal effects. Pflugers Arch. 469(10), 1313-1323 (2017).

    3. Sekine, R., Satoh, T., Takaoka, A., et al. Anti pruritic effects of topical crotamiton, capsaicin, and a corticosteroid on pruritogen-induced scratching behavior. Exp. Dermatol. 21(3), 201-204 (2012).