A prodrug form of 5-aminolevulinic acid
Related Products
Active Metabolite(s)
90019025-Aminolevulinic Acid (hydrochloride)
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Hexaminolevulinate (hydrochloride)

Item No. 23949

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-amino-4-oxo-pentanoic acid, hexyl ester, monohydrochloride
CAS Number
140898-91-5
Synonyms
  • 5-Aminolevulinic Acid hexyl ester
  • Hexyl 5- aminolevulinate
Molecular Formula
C11H21NO3 • HCl
Formula Weight
251.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/mlWater: 50 mg/ml
λmax
270 nm
SMILES
CCCCCCOC(CCC(CN)=O)=O.Cl
InChi Code
InChI=1S/C11H21NO3.ClH/c1-2-3-4-5-8-15-11(14)7-6-10(13)9-12;/h2-9,12H2,1H3;1H
InChi Key
LZYXPFZBAZTOCH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    250 mg

    $36

    Add

    500 mg

    $63

    Add

    1 g

    $103

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Hexaminolevulinate is a lipophilic, hexyl ester prodrug form of 5-aminolevulinic acid (Item No. 9001902).1 It produces equivalent protoporphyrin IX (PpIX) induction in WiDr and NHIK 3025 carcinoma cells at concentrations approximately 100-fold lower than 5-aminolevulinic acid. In vivo, hexaminolevulinate penetrates upper skin layers more effectively in pigs and induces higher levels of PpIX fluorescence in nude mice when compared with 5-aminolevulinic acid following topical administration.2 Formulations containing hexaminolevulinate have been used in imaging and photodynamic therapy for a variety of urogenital cancers.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gaullier, J.-M., Berg, K., Peng, Q., et al. Use of 5-aminolevulinic acid esters to improve photodynamic therapy on cells in culture. Cancer Res. 57(8), 1481-1486 (1997).

    2. Morrow, D.I.J., McCarron, P.A., Woolfson, A.D., et al. Hexyl aminolaevulinate is a more effective topical photosensitiser precursor than methyl aminolaevulinate and 5-aminolaevulinic acids when applied in equimolar doses. J. Pharm. Sci. 99(8), 3486-3498 (2010).