A prodrug form of isavuconazole
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Active Metabolite(s)
26211Isavuconazole
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Isavuconazonium (sulfate)

Item No. 23950

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methyl-glycine, [2-[[[1-[1-[(2R,3R)-3-[4-(4-cyanophenyl)-2-thiazolyl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-4H-1,2,4-triazolium-4-yl]ethoxy]carbonyl]methylamino]-3-pyridinyl]methyl ester, monosulfate
CAS Number
946075-13-4
Molecular Formula
C35H35F2N8O5S • HO4S
Formula Weight
814.8
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:5): 0.16 mg/mlEthanol: 10 mg/ml
λmax
273 nm
SMILES
O=C(CNC)OCC1=C(N(C)C(OC(C)[N+]2=CN(C[C@@](C3=CC(F)=CC=C3F)(O)[C@@H](C)C4=NC(C5=CC=C(C#N)C=C5)=CS4)N=C2)=O)N=CC=C1.O=S([O-])(O)=O
InChi Code
InChI=1S/C35H35F2N8O5S.H2O4S/c1-22(33-42-30(18-51-33)25-9-7-24(15-38)8-10-25)35(48,28-14-27(36)11-12-29(28)37)19-45-21-44(20-41-45)23(2)50-34(47)43(4)32-26(6-5-13-40-32)17-49-31(46)16-39-3;1-5(2,3)4/h5-14,18,20-23,39,48H,16-17,19H2,1-4H3;(H2,1,2,3,4)/q+1;/p-1/t22-,23?,35+;/m0./s1
InChi Key
LWXUIUUOMSMZKJ-KLFWAVJMSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Isavuconazonium is a prodrug form of the azole antifungal isavuconazole (ISA).1 Oral administration of isavuconazonium increases survival in rat models of azole-susceptible and -resistant A. fumigatus infection when administered at doses ranging from 0.25 to 512 mg/kg per day (ISA-equivalent = 0.12-245.8 mg/kg per day). Isavuconazonium reduces fungal burden and organism-mediated pulmonary injury and increases survival in a rabbit model of experimental invasive pulmonary aspergillosis when administered at ISA-equivalent doses ranging from 40 to 60 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Seyedmousavi, S., Brüggemann, R.J.M., Meis, J.F., et al. Pharmacodynamics of isavuconazole in an Aspergillus fumigatus mouse infection model. Antimicrob. Agents Chemother. 59(5), 2855-2866 (2015).

    2. Petraitis, V., Petraitiene, R., Moradi, P.W., et al. Pharmacokinetics and concentration-dependent efficacy of isavuconazole for treatment of experimental invasive pulmonary aspergillosis. Antimicrob. Agents Chemother. 60(5), 2718-2726 (2016).