Levomilnacipran (hydrochloride)

Levomilnacipran is an active enantiomer of the serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor milnacipran (Item No. 23837).¹ It binds to the 5-HT and NE transporters (K_is = 11.2 and 92.2 nM, respectively, for human recombinant transporters) and inhibits reuptake in vitro (IC₅₀s = 19 and 10.5 nM, respectively). It is selective for 5-HT and NE transporters over DAT (K_i = >10,000 nM for human recombinant DAT) and 23 receptors (K_is = ≥10,000 nM). Levomilnacipran increases extracellular levels of 5-HT and NE in rat cortex with minimal effective doses (MEDs) of 20 and 10 mg/kg, respectively. It decreases immobility in the forced swim and tail suspension tests (MEDs = 20 and 2.5 mg/kg, respectively) without increasing locomotor activity. Formulations containing levomilnacipran have been used in the treatment of major depressive disorder.

WARNING This product is not for human or veterinary use.

1. Auclair, A.L., Martel, J.C., Assié, M.B., et al. Levomilnacipran (F2695), a norepinephrine-preferring SNRI: Profile in vitro and in models of depression and anxiety. Neuropharmacology 70, 338-347 (2013).