An NHE-1 inhibitor
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KR-32568

Item No. 23968

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(aminoiminomethyl)-5-(5-fluoro-2-methylphenyl)-2-furancarboxamide
CAS Number
852146-73-7
Molecular Formula
C13H12FN3O2
Formula Weight
261.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: ~ 10 mg/ml
λmax
316 nm
SMILES
FC1=CC=C(C)C(C2=CC=C(C(NC(N)=N)=O)O2)=C1
InChi Code
InChI=1S/C13H12FN3O2/c1-7-2-3-8(14)6-9(7)10-4-5-11(19-10)12(18)17-13(15)16/h2-6H,1H3,(H4,15,16,17,18)
InChi Key
DTLDHYBZLVASJQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $76

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    5 mg

    $171

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    Product Description

    KR-32568 is an inhibitor of the sodium-hydrogen exchanger isoform-1 (NHE-1; IC50 = 230 nM).1 It restores cardiac contractile function ex vivo in an isolated ischemic rat heart model when used at a concentration of 10 μM. KR-32568 (0.3 mg/kg) reduces myocardial infarct size in a rat model of ischemia and reperfusion injury.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, S., Yi, K.Y., Hwang, S.K., et al. (5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1. J. Med. Chem. 48(8), 2882-2891 (2005).