A synthetic progestogen
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Hydroxyprogesterone Caproate

Item No. 23978

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
17-[(1-oxohexyl)oxy]-pregn-4-ene-3,20-dione
CAS Number
630-56-8
Synonyms
  • 17-Caproxyprogesterone
  • HPC
  • Hormofort
  • 17α-Hydroxyprogesterone Caproate
  • Hydroxyprogesterone Hexanoate
  • NSC 17592
  • Progesterone Caproate
Molecular Formula
C27H40O4
Formula Weight
428.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
240, 244 nm
SMILES
O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4(OC(CCCCC)=O)C(C)=O)=C1
InChi Code
InChI=1S/C27H40O4/c1-5-6-7-8-24(30)31-27(18(2)28)16-13-23-21-10-9-19-17-20(29)11-14-25(19,3)22(21)12-15-26(23,27)4/h17,21-23H,5-16H2,1-4H3/t21-,22+,23+,25+,26+,27+/m1/s1
InChi Key
DOMWKUIIPQCAJU-LJHIYBGHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Hydroxyprogesterone caproate is a synthetic progestogen.1 In vivo, hydroxyprogesterone caproate (3.32 mg/kg) reduces TNF-α-induced hypertension and decreases renal endothelin-1 (ET-1) production in pregnant rats. It reduces hypertension and production of TNF-α and IL-6 induced by reduction in uteroplacental perfusion (RUPP) in pregnant rats.2 Hydroxyprogesterone caproate also prevents preterm birth induced by L-NAME (Item No. 80210) in pregnant mice.3 Formulations containing hydroxyprogesterone caproate have been used for the prevention of preterm birth.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Keiser, S.D., Veillon, E.W., Parrish, M.R., et al. Effects of 17-hydroxyprogesterone on tumor necrosis factor-α-induced hypertension during pregnancy. Am. J. Hypertens. 22(10), 1120-1125 (2009).

    2. Veillon, E.W., Jr., Keiser, S.D., Parrish, M.R., et al. 17-Hydroxyprogesterone blunts the hypertensive response associated with reductions in uterine perfusion pressure in pregnant rats. Am. J. Obstet. Gynecol. 201(3), 324.e321-324.e326 (2009).

    3. Tiboni, G.M., Del Corso, A., and Marotta, F. Progestational agents prevent preterm birth induced by a nitric oxide synthesis inhibitor in the mouse. In Vivo 22(4), 447-450 (2008).